Hincks J R, Brindley W A
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;86(2):343-7. doi: 10.1016/0742-8413(87)90091-0.
Liver function and morphology of the mountain vole, Microtus montanus, were examined after i.p. injections of phenobarbital, beta-naphthoflavone, or Aroclor 1254 at three dose levels. The results of the liver function tests showed serum glutamic pyruvic transaminase and serum malathion carboxylesterase activities were normal in all the treatment groups. The histological results showed no necrotic tissue but did reveal two different morphological stages related to the level of monooxygenase activity; a low induction state was represented by foamy vacuolated hepatocytes while high induction states were related to enlarged, swollen, hypertrophied cells.
在对山地田鼠（Microtus montanus）腹腔注射三种剂量水平的苯巴比妥、β-萘黄酮或多氯联苯混合物Aroclor 1254后，对其肝脏功能和形态进行了检查。肝功能测试结果显示，所有治疗组的血清谷丙转氨酶和血清马拉硫磷羧酸酯酶活性均正常。组织学结果显示，未发现坏死组织，但确实揭示了与单加氧酶活性水平相关的两个不同形态阶段；低诱导状态表现为泡沫状空泡化肝细胞，而高诱导状态则与细胞增大、肿胀、肥大有关。
