不同诱导剂类型和剂量对山地田鼠（Microtus montanus）肝脏单加氧酶活性的影响。
Effects of varying inducer type and dose on hepatic monooxygenase activities in the mountain vole Microtus montanus.
作者信息
Hincks J R, Brindley W A
出版信息
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1986;85(2):385-9. doi: 10.1016/0742-8413(86)90213-6.
Hepatic monooxygenase activities of the mountain vole, Microtus montanus, were measured after i.p. injections of phenobarbital, B-naphthoflavone and Aroclor 1254 at doses ranging from 5 to 80 mg/kg. The results showed that mountain voles differed in their induction of hepatic monooxygenase activity relative to other rodents. The results also suggest substrate specificity in the detection of enzymatic induction and the importance of considering effects of varying inducer doses on hepatic monooxygenases.
经腹腔注射剂量范围为5至80毫克/千克的苯巴比妥、β-萘黄酮和多氯联苯混合物Aroclor 1254后，测定了山地田鼠（Microtus montanus）的肝脏单加氧酶活性。结果表明，与其他啮齿动物相比，山地田鼠在肝脏单加氧酶活性诱导方面存在差异。结果还表明，在检测酶诱导时存在底物特异性，以及考虑不同诱导剂剂量对肝脏单加氧酶的影响的重要性。
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