Boyd P J, Walker R J
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;86(2):371-3. doi: 10.1016/0742-8413(87)90097-1.
Intracellular recordings were made from a selection of identified neurons in the sub-oesophageal ganglia of Helix aspersa, and their responses to the molluscan neuropeptides FMRF-amide and pQDPFLRF-amide compared. While FMRF-amide excited certain neurons and inhibited others, pQDPFLRF-amide did not produce excitation in any of the cells tested. A few cells were unresponsive to pQDPFLRF-amide, but most were inhibited with varying potency. FMRF-amide was generally 10-100 times more potent than pQDPFLRF-amide, but one cell, E13 in the visceral ganglion, showed equal sensitivity to the two peptides. On most cells there was no clear evidence for cross desensitization between the two peptides, although it is possible that in some cases where both peptides are inhibitory they may be acting on a single receptor.
对玛瑙螺食管下神经节中选定的特定神经元进行了细胞内记录，并比较了它们对软体动物神经肽FMRF酰胺和pQDPFLRF酰胺的反应。虽然FMRF酰胺能使某些神经元兴奋而抑制另一些神经元，但pQDPFLRF酰胺在任何测试细胞中均未产生兴奋作用。少数细胞对pQDPFLRF酰胺无反应，但大多数细胞受到不同程度的抑制。FMRF酰胺的效力通常比pQDPFLRF酰胺高10 - 100倍，但在内脏神经节中的一个细胞（E13）对这两种肽表现出同等的敏感性。在大多数细胞上，没有明确证据表明这两种肽之间存在交叉脱敏现象，不过在某些情况下，当两种肽都具有抑制作用时，它们可能作用于单一受体。
