• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

对来自蜗牛（Helix aspersa）大脑的一种新型心脏抑制肽的部分特性分析。

Partial characterization of a novel cardioinhibitory peptide from the brain of the snail Helix aspersa.

作者信息

Baud C, Darbon P, Li K W, Marchand C R

机构信息

Laboratoire de Biologie des Organismes et Ecosystèmes, UFR Sciences et Techniques, Besançon, France.

出版信息

Cell Mol Neurobiol. 1998 Aug;18(4):413-24. doi: 10.1023/a:1022549515664.

DOI:10.1023/a:1022549515664
PMID:9619296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11560247/
Abstract
  1. We report the isolation of a peptide from the brain of the snail Helix aspersa by radioimmunoassay using an antisomatostatin. 2. The sequencing of an immunopositive fraction showed the presence of a new tridecapeptide, termed Helix cardioinhibitory peptide (HCIP), with the following primary structure: H-Val-Phe-Gln-Asn-Gln-Phe-Lys-Gly-Ile-Gln-Gly-Arg-Phe-NH2. It is structurally related to the Achatina cardioexcitatory peptide (ACEP-1) and the terminal-amino acid sequence of HCIP is identical to that of FMRFamide family peptides. 3. The synthetic HCIP was tested on heart and neuronal activities and it was found to have inhibitory actions not only on the ventricle but also on visceral neurons of the central nervous system of Helix. Immunocytochemical investigation indicates its presence in visceral and parietal ganglia, in which cells taking part in the regulation of the heartbeat have been previously identified.
摘要
  1. 我们通过使用抗生长抑素的放射免疫分析法，报告了从蜗牛（Helix aspersa）大脑中分离出一种肽。2. 对免疫阳性部分进行测序显示存在一种新的十三肽，称为螺旋心脏抑制肽（HCIP），其一级结构如下：H-缬氨酸-苯丙氨酸-谷氨酰胺-天冬酰胺-谷氨酰胺-苯丙氨酸-赖氨酸-甘氨酸-异亮氨酸-谷氨酰胺-甘氨酸-精氨酸-苯丙氨酸-NH2。它在结构上与玛瑙螺心脏兴奋肽（ACEP-1）相关，并且HCIP的末端氨基酸序列与FMRF酰胺家族肽的序列相同。3. 对合成的HCIP进行了心脏和神经元活性测试，发现它不仅对心室有抑制作用，而且对蜗牛中枢神经系统的内脏神经元也有抑制作用。免疫细胞化学研究表明它存在于内脏神经节和壁神经节中，在这些神经节中先前已鉴定出参与心跳调节的细胞。

相似文献

1
Partial characterization of a novel cardioinhibitory peptide from the brain of the snail Helix aspersa.对来自蜗牛（Helix aspersa）大脑的一种新型心脏抑制肽的部分特性分析。
Cell Mol Neurobiol. 1998 Aug;18(4):413-24. doi: 10.1023/a:1022549515664.
2
Identifiable Achatina giant neurones: their localizations in ganglia, axonal pathways and pharmacological features.可识别的玛瑙螺巨型神经元：它们在神经节中的定位、轴突通路及药理学特性
Gen Pharmacol. 1996 Jan;27(1):3-32. doi: 10.1016/0306-3623(95)00113-1.
3
Further mapping of the Achatina giant neurone types sensitive to the neuroactive peptides isolated from invertebrates.对非洲大蜗牛中对从无脊椎动物分离出的神经活性肽敏感的巨型神经元类型进行进一步绘图。
Gen Pharmacol. 1995 Dec;26(8):1701-8. doi: 10.1016/0306-3623(95)00045-3.
4
The actions of FMRFamide-like peptides on visceral and somatic muscles of the snail Helix aspersa.
J Exp Biol. 1987 Sep;131:55-68. doi: 10.1242/jeb.131.1.55.
5
A novel cardio-excitatory peptide isolated from the atria of the African giant snail, Achatina fulica.
Biochem Biophys Res Commun. 1990 Mar 16;167(2):777-83. doi: 10.1016/0006-291x(90)92093-f.
6
An initial screen of a series of neuroactive peptides for activity on identified central neurones of Helix aspersa.
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1992 Nov;103(3):441-51. doi: 10.1016/0742-8413(92)90163-2.
7
A novel cDNA sequence encoding the precursor of the D-amino acid-containing neuropeptide fulicin and multiple alpha-amidated neuropeptides from Achatina fulica.一种编码含D-氨基酸的神经肽福寿螺毒素前体以及来自福寿螺的多种α-酰胺化神经肽的新cDNA序列。
J Neurochem. 1995 May;64(5):2248-55. doi: 10.1046/j.1471-4159.1995.64052248.x.
8
The peptide pQFYRFamide is encoded on the FMRFamide precursor of the snail Helix aspersa but does not activate the FMRFamide-gated sodium current.
Biol Bull. 1996 Dec;191(3):341-52. doi: 10.2307/1543007.
9
Characterization of cDNA and expression of mRNA encoding an Achatina cardioexcitatory RFamide peptide.
Peptides. 1999 Nov;20(11):1295-302. doi: 10.1016/s0196-9781(99)00134-5.
10
Further study on the effects of achatin-I, an Achatina endogenous neuroexcitatory tetrapeptide having a D-phenylalanine residue, on Achatina neurones.对玛瑙螺内源性神经兴奋性四肽玛瑙螺素-I（具有一个D-苯丙氨酸残基）对玛瑙螺神经元作用的进一步研究。
Acta Biol Hung. 1995;46(2-4):395-400.

引用本文的文献

1
The neuronal control of cardiac functions in Molluscs.软体动物心脏功能的神经元控制。
Comp Biochem Physiol A Mol Integr Physiol. 2011 Oct;160(2):102-16. doi: 10.1016/j.cbpa.2011.06.014. Epub 2011 Jun 25.

本文引用的文献

1
Processing, axonal transport and cardioregulatory functions of peptides derived from two related prohormones generated by alternative splicing of a single gene in identified neurons VD1 and RPD2 of Lymnaea.源自通过椎实螺特定神经元VD1和RPD2中单个基因的可变剪接产生的两种相关前激素的肽的加工、轴突运输和心脏调节功能。
Brain Res Mol Brain Res. 1994 Apr;23(1-2):66-72. doi: 10.1016/0169-328x(94)90212-7.
2
Elucidation by FAB-MS of the structure of a new cardioactive peptide from Aplysia.利用快原子轰击质谱法阐明来自海兔的一种新型心脏活性肽的结构。
Nature. 1982 Dec 16;300(5893):643-5. doi: 10.1038/300643a0.
3
Multiple actions of a molluscan cardioexcitatory neuropeptide and related peptides on identified Helix neurones.一种软体动物心脏兴奋神经肽及相关肽对已鉴定的螺旋神经元的多种作用。
J Physiol. 1984 Nov;356:315-33. doi: 10.1113/jphysiol.1984.sp015467.
4
Two endogenous neuropeptides modulate the gill and siphon withdrawal reflex in Aplysia by presynaptic facilitation involving cAMP-dependent closure of a serotonin-sensitive potassium channel.两种内源性神经肽通过涉及环磷酸腺苷（cAMP）依赖性关闭5-羟色胺敏感钾通道的突触前易化作用，调节海兔的鳃和虹吸管退缩反射。
Proc Natl Acad Sci U S A. 1984 Dec;81(24):7956-60. doi: 10.1073/pnas.81.24.7956.
5
Neural control of circulation in Aplysia. II. Interneurons.
J Neurophysiol. 1974 May;37(3):476-96. doi: 10.1152/jn.1974.37.3.476.
6
Neural control of circulation in Aplysia. I. Motoneurons.
J Neurophysiol. 1974 May;37(3):458-75. doi: 10.1152/jn.1974.37.3.458.
7
The actions of FMRFamide-like peptides on visceral and somatic muscles of the snail Helix aspersa.
J Exp Biol. 1987 Sep;131:55-68. doi: 10.1242/jeb.131.1.55.
8
Sequence of small cardioactive peptide A: a second member of a class of neuropeptides in Aplysia.小活性心肽A的序列：海兔体内一类神经肽的第二个成员。
Peptides. 1987 Jan-Feb;8(1):179-84. doi: 10.1016/0196-9781(87)90184-7.
9
A neuropeptide precursor expressed in Aplysia neuron L5.一种在海兔神经元L5中表达的神经肽前体。
DNA. 1986 Jun;5(3):203-8. doi: 10.1089/dna.1986.5.203.
10
Comparison of the effects of FMRF-amide and pQDPFLRF-amide on identified Helix neurons.FMRF酰胺和pQDPFLRF酰胺对已鉴定的螺旋神经元的作用比较。
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;86(2):371-3. doi: 10.1016/0742-8413(87)90097-1.