Serio Gabriella, Pezzuto Federica, Marzullo Andrea, Scattone Anna, Cavone Domenica, Punzi Alessandra, Fortarezza Francesco, Gentile Mattia, Buonadonna Antonia Lucia, Barbareschi Mattia, Vimercati Luigi
Department of Emergency and Organ Transplantation, Division of Pathology, Medical School, University of Bari, 11 G. Cesare Square, 70124 Bari, Italy.
Division of Pathology, IRCCS, National Cancer Institute "Giovanni Paolo II", 70124 Bari, Italy.
Int J Mol Sci. 2017 Aug 22;18(8):1818. doi: 10.3390/ijms18081818.
Malignant mesothelioma is a rare and aggressive tumor with limited therapeutic options. We report a case of a malignant peritoneal mesothelioma (MPM) epithelioid type, with environmental asbestos exposure, in a 36-year-old man, with a long survival (17 years). The patient received standard treatment which included cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).
Molecular analysis with comparative genomic hybridization (CGH)-array was performed on paraffin-embedded tumoral samples. Multiple chromosomal imbalances were detected. The gains were prevalent. Losses at 1q21, 2q11.1→q13, 8p23.1, 9p12→p11, 9q21.33→q33.1, 9q12→q21.33, and 17p12→p11.2 are observed. Chromosome band 3p21 (), 9p21 () and 22q12 () are not affected. the defects observed in this case are uncommon in malignant peritoneal mesothelioma. Some chromosomal aberrations that appear to be random here, might actually be relevant events explaining the response to therapy, the long survival and, finally, may be considered useful prognostic factors in peritoneal malignant mesothelioma (PMM).
恶性间皮瘤是一种罕见且侵袭性强的肿瘤，治疗选择有限。我们报告一例36岁男性的上皮样型恶性腹膜间皮瘤（MPM）病例，该患者有环境石棉暴露史，生存期较长（17年）。患者接受了包括细胞减灭术（CRS）和腹腔内热化疗（HIPEC）在内的标准治疗。
对石蜡包埋的肿瘤样本进行了比较基因组杂交（CGH）阵列的分子分析。检测到多个染色体失衡。增益较为普遍。观察到1q21、2q11.1→q13、8p23.1、9p12→p11、9q21.33→q33.1、9q12→q21.33和17p12→p11.2区域的缺失。染色体带3p21（）、9p21（）和22q12（）未受影响。本病例中观察到的缺陷在恶性腹膜间皮瘤中并不常见。这里一些看似随机的染色体畸变，可能实际上是解释治疗反应、长生存期的相关事件，最终可能被视为腹膜恶性间皮瘤（PMM）有用的预后因素。
