Asano R, Hokari S
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1987;86(2):443-7. doi: 10.1016/0742-8413(87)90111-3.
The effect of copper on intact swine erythrocytes was investigated in vitro. When treated with copper, a decrease in the GSH content, accumulation of copper in the cell, loss of potassium and gain of sodium, cross-linking of membrane proteins and echinocytic transformation were observed. All of these phenomena seem to be caused by a potent oxidant action of copper. These cytotoxic effects of copper were markedly inhibited by the addition of bovine serum albumin in the incubation medium. These results may help to understand the mechanism of hemolysis associated with copper poisoning in vivo.
在体外研究了铜对完整猪红细胞的影响。用铜处理时，观察到谷胱甘肽含量降低、细胞内铜积累、钾流失和钠增加、膜蛋白交联以及棘状红细胞转化。所有这些现象似乎都是由铜的强氧化作用引起的。在孵育培养基中添加牛血清白蛋白可显著抑制铜的这些细胞毒性作用。这些结果可能有助于理解体内与铜中毒相关的溶血机制。
