Chagas B S, Gurgel A P A D, Paiva Júnior S S L, Lima R C P, Cordeiro M N, Moura R R, Coelho A V C, Nascimento K C G, Silva Neto J C, Crovella S, Freitas A C
Laboratório de Estudos Moleculares e Terapia Experimental, Departamento de Genética, , , Brasil.
Departamento de Engenharia e Meio Ambiente, Universidade Federal da Paraíba, Rio Tinto, PB, Brasil.
Genet Mol Res. 2017 Aug 17;16(3):gmr-16-03-gmr.16039742. doi: 10.4238/gmr16039742.
Human papillomavirus (HPV) infection is considered a risk factor for cervical cancer. Even if the high-risk HPV (HR-HPV) infection is necessary, environmental co-factors and genetic susceptibility also play an important role in cervical cancer development. In this study, a possible association of rs1695 GSTP1 polymorphisms, HR-HPV infection, and oral contraceptive use with cancer lesion development in women was investigated. The study population comprised 441 Brazilian women from the Northeast region including 98 HPV-infected women with high-grade squamous intraepithelial lesions, 77 HPV-infected women with low-grade squamous intraepithelial lesions, and 266 HPV-negative women with no lesion, used as a control. Our data did not show a significant association between the GSTP1 polymorphism A/G (rs1695) and any HPV-related cervical abnormalities. However, considering the use of oral contraceptives, the GSTP1 rs1695 polymorphism was associated with higher susceptibility to the development of cervical lesions in HR-HPV-infected women. Our study suggests a synergic effect of oral contraceptive use, GSTP1 polymorphisms, and HR-HPV infection in the development of cervical lesions. Together, these risk factors may induce neoplastic transformation of the cervical squamous epithelium, setting conditions for secondary genetic events leading to cervical cancer.
人乳头瘤病毒（HPV）感染被认为是宫颈癌的一个风险因素。即使高危型HPV（HR-HPV）感染是必要条件，环境协同因素和遗传易感性在宫颈癌的发生发展中也起着重要作用。在本研究中，调查了rs1695 GSTP1基因多态性、HR-HPV感染及口服避孕药的使用与女性癌症病变发展之间可能存在的关联。研究人群包括来自巴西东北部地区的441名女性，其中98名HPV感染且患有高级别鳞状上皮内病变的女性、77名HPV感染且患有低级别鳞状上皮内病变的女性，以及266名HPV阴性且无病变的女性作为对照。我们的数据未显示GSTP1基因多态性A/G（rs1695）与任何HPV相关的宫颈异常之间存在显著关联。然而，考虑到口服避孕药的使用情况，GSTP1 rs1695基因多态性与HR-HPV感染女性发生宫颈病变的易感性较高有关。我们的研究表明，口服避孕药的使用、GSTP1基因多态性和HR-HPV感染在宫颈病变发展中具有协同作用。这些风险因素共同作用可能诱导宫颈鳞状上皮发生肿瘤转化，为导致宫颈癌的继发遗传事件创造条件。
