Kim Nari, Youn Chang Ho, Kim A Sol, Ko Hae Jin, Kim Hyo Min, Moon Hana, Park Sujung
Department of Family Medicine, Kyungpook National University School of Medicine, Daegu, Korea.
Department of Family Medicine, Kyungpook National University Chilgok Hospital, Daegu, Korea.
Korean J Gastroenterol. 2017 Aug 25;70(2):81-88. doi: 10.4166/kjg.2017.70.2.81.
BACKGROUND/AIMS: Chronic atrophic gastritis (AG) and intestinal metaplasia (IM) of the stomach are premalignant lesions. The present study aimed to examine the associations between obesity and these lesions.
A total of 2,997 patients, who underwent gastroscopy, participated in this study, excluding those who had been diagnosed with gastric cancer. Participants were divided into four groups based on their body mass index (BMI). The risk of AG and IM with increasing BMI was analyzed in men and women, separately.
The association between BMI and AG was not significant. After adjusting for age, smoking, alcohol, and AG, the odds ratios for IM in the overweight, obesity, and severe obesity groups were 2.25 (95% confidence interval [CI], 1.50-3.37), 2.32 (95% CI, 1.58-3.42), and 4.86 (95% CI, 2.04-11.5) in men, and 2.66 (95% CI, 1.29-5.47), 4.46 (95% CI, 2.28-8.75), and 9.57 (95% CI, 3.26-28.12) in women, compared with the normal BMI group.
Gastric IM was significantly associated with increased BMI.
背景/目的：慢性萎缩性胃炎（AG）和胃肠化生（IM）是癌前病变。本研究旨在探讨肥胖与这些病变之间的关联。
共有2997例接受胃镜检查的患者参与本研究，排除已诊断为胃癌的患者。参与者根据体重指数（BMI）分为四组。分别分析男性和女性中BMI增加时AG和IM的风险。
BMI与AG之间的关联不显著。在调整年龄、吸烟、饮酒和AG后，超重、肥胖和重度肥胖组男性发生IM的比值比分别为2.25（95%置信区间[CI]，1.50 - 3.37）、2.32（95%CI，1.58 - 3.42）和4.86（95%CI，2.04 - 11.5），女性分别为2.66（95%CI，1.29 - 5.47）、4.46（95%CI，2.28 - 8.75）和9.57（95%CI，3.26 - 28.12），与正常BMI组相比。
胃IM与BMI增加显著相关。
