Ramamoorthy Venkataraghavan, Campa Adriana, Rubens Muni, Martinez Sabrina S, Fleetwood Christina, Stewart Tiffanie, Liuzzi Juan P, George Florence, Khan Hafiz, Li Yinghui, Baum Marianna K
J Assoc Nurses AIDS Care. 2017 Nov-Dec;28(6):897-906. doi: 10.1016/j.jana.2017.07.008. Epub 2017 Jul 31.
We explored the relationship between caffeine consumption, insomnia, and HIV disease progression (CD4+ T cell counts and HIV viral loads). Caffeine intake and insomnia levels were measured using the Modified Caffeine Consumption Questionnaire and the Pittsburgh Insomnia Rating Scale (PIRS) in 130 clinically stable participants who were living with HIV, taking antiretroviral therapy, and recruited from the Miami Adult Studies on HIV cohort. Linear regressions showed that caffeine consumption was significantly and adversely associated with distress score, quality-of-life score, and global PIRS score. Linear regression analyses also showed that global PIRS score was significantly associated with lower CD4+ T cell counts and higher HIV viral loads. Caffeine could have precipitated insomnia in susceptible people living with HIV, which could be detrimental to their disease progression states.
我们探究了咖啡因摄入量、失眠与HIV疾病进展（CD4+ T细胞计数和HIV病毒载量）之间的关系。在130名临床状况稳定、感染HIV、正在接受抗逆转录病毒治疗且招募自迈阿密成人HIV队列研究的参与者中，使用改良咖啡因摄入量问卷和匹兹堡失眠评定量表（PIRS）来测量咖啡因摄入量和失眠水平。线性回归分析显示，咖啡因摄入量与痛苦评分、生活质量评分以及PIRS总评分之间存在显著的负相关。线性回归分析还表明PIRS总评分与较低的CD4+ T细胞计数和较高的HIV病毒载量显著相关。咖啡因可能会使易患失眠症的HIV感染者出现失眠症状，并可能对其疾病进展状况产生不利影响。
