Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Schizophr Res. 2018 May;195:283-285. doi: 10.1016/j.schres.2017.08.026. Epub 2017 Aug 19.
This study was designed to explore the relationship in between the daily consumption of fish oil (360mg DHA+540mg EPA), and reduction of symptoms and violent behavior among patients with schizophrenia.
Fifty inpatients meeting ICD-10 criteria for schizophrenia and scoring more than four of Modified Overt Aggression Scale (MOAS) with antipsychotics treatment were randomly assigned to receive either fish oil (N=28) or a placebo (N=22) in a twelve week, double-blind supplementation trial. Assessments were performed at baseline and at weeks 4, 8 and 12.
The PANSS and CGI scores decreased at the week of 4, 8 and 12, but no differences were found between the two groups. MOAS scores declined significantly at weeks 4, 8 and 12. At week 12, MOAS scores of the fish oil group declined significantly than the placebo group (t=-2.40, P<0.05).
violent schizophrenia patients treated with fish oil (360mg DHA+540mg EPA) demonstrated a decrease in violence, but improvement in positive and negative symptoms was no greater than patients treated with the placebo after twelve weeks.
本研究旨在探讨每日摄入鱼油（360mgDHA+540mGEPA）与精神分裂症患者症状和暴力行为减少之间的关系。
50 名符合 ICD-10 精神分裂症标准且经抗精神病药物治疗后改良外显攻击量表（MOAS）评分超过 4 分的住院患者被随机分配至鱼油组（n=28）或安慰剂组（n=22），进行为期 12 周的双盲补充试验。在基线和第 4、8 和 12 周进行评估。
PANSS 和 CGI 评分在第 4、8 和 12 周下降，但两组之间没有差异。MOAS 评分在第 4、8 和 12 周显著下降。在第 12 周，鱼油组的 MOAS 评分显著低于安慰剂组（t=-2.40，P<0.05）。
接受鱼油（360mgDHA+540mGEPA）治疗的暴力精神分裂症患者暴力行为减少，但在 12 周后，阳性和阴性症状的改善并不大于安慰剂组。
