Peters Sue, Wadden Katie P, Hayward Kathryn S, Neva Jason L, Auriat Angela M, Boyd Lara A
University of British Columbia, Faculty of Medicine, Department of Physical Therapy, 212-2177 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.
University of British Columbia, Faculty of Medicine, Department of Physical Therapy, 212-2177 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada; Stroke Division, The Florey Institute of Neuroscience and Mental Health, University of Melbourne, 245 Burgundy Road, Heidelberg, Victoria 3084, Australia; NHMRC Centre of Research Excellence in Stroke Rehabilitation and Brain Recovery, Australia.
Neurosci Lett. 2017 Sep 29;658:155-160. doi: 10.1016/j.neulet.2017.08.036. Epub 2017 Aug 19.
Combining structural and functional magnetic resonance imaging may provide insight into how residual motor networks contribute to motor outcomes post-stroke. The purpose of this study was to examine whether a structural motor network (SMN), generated with fMRI guided diffusion-based tractography, relates to motor function post-stroke. Twenty-seven individuals with mild to moderate upper limb impairment post stroke underwent diffusion magnetic resonance imaging. A bilateral motor network mask guided white matter tractography for each participant. Fractional anisotrophy (FA) was calculated for the SMN and corticospinal tracts (CST). The Wolf Motor Function Test (WMFT) rate and Fugl-Meyer Upper Limb (FM) tests characterized arm function and impairment respectively. The SMN and ipsilesional CST together explained approximately 35% of the variance in paretic arm function (WMFT-rate p=0.006). This study demonstrates that a broader motor network, like the SMN, is functionally meaningful. Given that the motor network is widely distributed, the proposed SMN warrants further investigation as a potential adjunct biomarker to characterize recovery potential after stroke.
结合结构和功能磁共振成像可能有助于深入了解残余运动网络如何促进中风后的运动结果。本研究的目的是检查通过功能磁共振成像引导的基于扩散的纤维束成像生成的结构运动网络（SMN）是否与中风后的运动功能相关。27名中风后有轻度至中度上肢损伤的个体接受了扩散磁共振成像。为每个参与者使用双侧运动网络模板引导白质纤维束成像。计算了SMN和皮质脊髓束（CST）的分数各向异性（FA）。Wolf运动功能测试（WMFT）评分和Fugl-Meyer上肢（FM）测试分别用于表征手臂功能和损伤情况。SMN和患侧CST共同解释了患侧手臂功能约35%的变异（WMFT评分p=0.006）。本研究表明，像SMN这样更广泛的运动网络在功能上具有重要意义。鉴于运动网络分布广泛，所提出的SMN作为一种潜在的辅助生物标志物，用于表征中风后的恢复潜力，值得进一步研究。
