FOX 家族成员可能成为癌症的药物靶点。

Members of FOX family could be drug targets of cancers.

机构信息

The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 100050 Beijing, China; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 100050 Beijing, China.

Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 100050 Beijing, China.

出版信息

Pharmacol Ther. 2018 Jan;181:183-196. doi: 10.1016/j.pharmthera.2017.08.003. Epub 2017 Aug 19.

DOI:10.1016/j.pharmthera.2017.08.003

PMID:28830838

Abstract

FOX families play important roles in biological processes, including metabolism, development, differentiation, proliferation, apoptosis, migration, invasion and longevity. Here we are focusing on roles of FOX members in cancers, FOX members and drug resistance, FOX members and stem cells. Finally, FOX members as drug targets of cancer treatment were discussed. Future perspectives of FOXC1 research were described in the end.

摘要

FOX 家族在生物过程中发挥着重要作用，包括代谢、发育、分化、增殖、凋亡、迁移、侵袭和长寿。在这里，我们重点介绍 FOX 成员在癌症中的作用、FOX 成员与耐药性、FOX 成员与干细胞。最后，讨论了 FOX 成员作为癌症治疗的药物靶点。最后描述了 FOXC1 研究的未来展望。