已确诊类风湿关节炎患者手部骨密度与关节破坏之间的相关性
Correlation between hand bone mineral density and joint destruction in established rheumatoid arthritis.
作者信息
Mochizuki Takeshi, Yano Koichiro, Ikari Katsunori, Hiroshima Ryo, Sakuma Yu, Momohara Shigeki
机构信息
Department of Orthopaedic Surgery, Kamagaya General Hospital, Chiba, Japan.
Institute of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan.
出版信息
J Orthop. 2017 Aug 2;14(4):461-465. doi: 10.1016/j.jor.2017.07.010. eCollection 2017 Dec.
OBJECTIVE
We aimed to clarify the correlation between bone mineral density (BMD) and the modified total Sharp score of the hand in Japanese patients with established rheumatoid arthritis (RA).
METHODS
We examined the hands of 57 patients who had RA for more than 20 years. BMD for the whole hand was measured using dual-energy x-ray absorptiometry. Concurrently, the hands were analyzed using radiography to estimate the van der Heijde-modified total Sharp score (vdH-S).
RESULTS
The patients were all women with a median age of 69.7 years and RA disease duration of 29.9 years. The correlation coefficients were -0.513 (P < 0.0001) for hand BMD and vdH-S of the hand, -0.576 (P < 0.0001) for hand BMD and the erosion score of the vdH-S, and -0.339 (P < 0.0001) for hand BMD and the joint narrowing score of the vdH-S.
CONCLUSIONS
Hand BMD is correlated with the vdH-S in long-established RA. The hand BMD is important for structural assessment of the hand. Additionally, we may be able to predict the vdH-S of the hand on the basis of the hand BMD in long-established RA.
目的
我们旨在阐明日本类风湿关节炎（RA）确诊患者的骨密度（BMD）与手部改良总Sharp评分之间的相关性。
方法
我们检查了57例患RA超过20年的患者的手部。使用双能X线吸收法测量全手的骨密度。同时，对手部进行X线分析以评估范德海伊德改良总Sharp评分（vdH-S）。
结果
患者均为女性，中位年龄69.7岁，RA病程29.9年。手部骨密度与手部vdH-S的相关系数为-0.513（P<0.0001），手部骨密度与vdH-S的侵蚀评分的相关系数为-0.576（P<0.0001），手部骨密度与vdH-S的关节狭窄评分的相关系数为-0.339（P<0.0001）。
结论
在病程较长的RA中，手部骨密度与vdH-S相关。手部骨密度对于手部结构评估很重要。此外，在病程较长的RA中，我们或许能够根据手部骨密度预测手部的vdH-S。
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