全髋关节置换术中血浆和尿液中的凝血酶原片段F1+2
Prothrombin fragment F1+2 in plasma and urine during total hip arthroplasty.
作者信息
Borgen Pål O, Reikeras Olav
机构信息
Department of Orthopedics, Martina Hansens Hospital, Norway.
Department of Orthopedics, Oslo University Hospital, Rikshospitalet, Norway.
出版信息
J Orthop. 2017 Aug 3;14(4):475-479. doi: 10.1016/j.jor.2017.08.001. eCollection 2017 Dec.
OBJECTIVE
To study the time course and correlation of prothrombin fragment (F1 + 2) in plasma and urine during THA.
METHOD
F1 + 2 concentrations were recorded at four time-points during THA.
RESULTS
F1 + 2 increased during surgery. In contrast to urine, plasma F1 + 2 was temporarily reduced the first postoperative day. At day six, plasma F1 + 2 was significantly elevated indicating on-going thrombin activation, while urine F1 + 2 was normalized.
CONCLUSION
The response in coagulation to operative trauma can be recorded with F1 + 2 both in plasma and urine. We were not able to demonstrate any correlation of F1 + 2 in plasma and urine later in the postoperative period.
目的
研究全髋关节置换术（THA）期间血浆和尿液中凝血酶原片段（F1 + 2）的时间进程及相关性。
方法
在THA期间的四个时间点记录F1 + 2浓度。
结果
手术期间F1 + 2升高。与尿液不同，术后第一天血浆F1 + 2暂时降低。在第六天，血浆F1 + 2显著升高，表明凝血酶持续激活，而尿液F1 + 2恢复正常。
结论
血浆和尿液中的F1 + 2均可记录凝血对手术创伤的反应。我们未能证明术后后期血浆和尿液中F1 + 2之间存在任何相关性。
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