大西洋鳕鱼（）血浆中一种类白蛋白蛋白的鉴定及其作为多环芳烃污染生物标志物的潜力。
Identification of an albumin-like protein in plasma of Atlantic cod () and its biomarker potential for PAH contamination.
作者信息
Enerstvedt Karianne Skogland, Sydnes Magne O, Pampanin Daniela M
机构信息
International Research Institute of Stavanger (IRIS) - Environmental Department, Mekjarvik 12, NO-4070 Randaberg, Norway.
Faculty of Science and Technology, Department of Mathematics and Natural Science, University of Stavanger, NO-4036 Stavanger, Norway.
出版信息
Heliyon. 2017 Aug 10;3(8):e00367. doi: 10.1016/j.heliyon.2017.e00367. eCollection 2017 Aug.
Increased research efforts are currently focusing on Atlantic cod () and its significance for monitoring the contaminant situation in marine environments. Polycyclic aromatic hydrocarbons (PAHs) are well known toxic and carcinogenic compounds, thus continuous monitoring is required to ensure ecosystem sustainability and human food safety. A sensitive biomarker of PAH exposure in humans is the detection of PAH metabolites bound to albumin in blood. The potential of a similar PAH-albumin biomarker in Atlantic cod was therefore investigated by a desktop bioinformatic study followed by liquid chromatography mass spectrometry/mass spectrometry analysis of plasma from 16 fish. For the first time, an albumin-like protein in plasma of Atlantic cod is described, and the biomarker potential based on PAH-albumin adduct detection is discussed. Due to the detected low abundance of the albumin-like protein, it was found unlikely to be applicable as a new biomarker tool for evaluation of PAH exposure.
目前，更多的研究工作集中在大西洋鳕鱼（）及其在监测海洋环境污染物状况方面的意义。多环芳烃（PAHs）是众所周知的有毒和致癌化合物，因此需要持续监测以确保生态系统的可持续性和人类食品安全。人类接触PAH的一种敏感生物标志物是检测血液中与白蛋白结合的PAH代谢物。因此，通过桌面生物信息学研究，随后对16条鱼的血浆进行液相色谱质谱/质谱分析，研究了大西洋鳕鱼中类似PAH-白蛋白生物标志物的潜力。首次描述了大西洋鳕鱼血浆中的一种类白蛋白蛋白，并讨论了基于PAH-白蛋白加合物检测的生物标志物潜力。由于检测到类白蛋白蛋白的丰度较低，发现它不太可能作为评估PAH暴露的新生物标志物工具。
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