IRCCS Centro Neurolesi "Bonino-Pulejo", Via P.le Palermo S.S. 113 - CAP, 98124, Messina, Italy.
Department of Human Pathology, University Hospital of Messina, Via Consolare Valeria, Messina, Italy.
Neurol Sci. 2017 Nov;38(11):2007-2013. doi: 10.1007/s10072-017-3094-3. Epub 2017 Aug 22.
Simultaneous performance of motor and cognitive tasks may compete for common brain network resources in aging or patients with some neurological diseases, suggesting the occurrence of a cognitive-motor interference. While this phenomenon has been well described for multiple sclerosis (MS) patients, it never has been tested on asymptomatic subject with magnetic resonance imaging (MRI) findings suggestive of demyelinating disease (i.e., radiologically isolated syndrome: RIS). In this pilot study, 10 RIS subjects and 10 sex/age-matched healthy controls were tested by means of static posturography under eyes opened (single-task trial) and while performing two different cognitive tasks (semantic modified word list generation for first dual-task trial and phonemic semantic modified word list generation for second dual-task trial), to estimate the dual-task cost (DTC) of standing balance. In our sample, under cognitive interference (without any substantial differences between semantic and phonemic modified word list generation), the RIS group showed significance differences in CoP (center of pressure) total sway area, ellipse eccentricity, CoP sway path length, CoP median sway velocity along the AP (anteroposterior) axis and along the ML (mediolateral) axis, reflecting a higher negative DTC respect to healthy subjects (which have simply shown a statistical trend, failing to reach a significance, in some trials). The phenomenon of cognitive-motor interference might be unmasked by a dual-task posturography in RIS subjects, too. We hypothesize that this approach could be useful to early reveal the presence of a demyelinating disease and to reach a MS diagnosis in subjects otherwise classified as RIS.
在衰老或某些神经疾病患者中，同时进行运动和认知任务可能会争夺共同的大脑网络资源，这表明存在认知-运动干扰。虽然这种现象在多发性硬化症 (MS) 患者中已经得到很好的描述，但从未在 MRI 检查结果提示脱髓鞘疾病（即，孤立综合征：RIS）的无症状受试者中进行过测试。在这项初步研究中，10 名 RIS 受试者和 10 名性别/年龄匹配的健康对照者通过睁眼静态姿势描记术（单任务试验）和同时执行两项不同的认知任务（语义修改词列表生成，用于第一次双重任务试验，以及语音语义修改词列表生成，用于第二次双重任务试验）进行测试，以估计站立平衡的双重任务成本 (DTC)。在我们的样本中，在认知干扰下（语义和语音修改词列表生成之间没有任何实质性差异），RIS 组的 CoP（压力中心）总摇摆面积、椭圆偏心率、CoP 摇摆路径长度、CoP 沿 AP（前后）轴和 ML（左右）轴的中值摇摆速度存在显着差异，反映出与健康受试者相比，更高的负 DTC（而健康受试者仅在某些试验中显示出统计学趋势，但未能达到显着性）。认知-运动干扰现象也可能在 RIS 受试者中通过双重任务姿势描记术揭示出来。我们假设这种方法可以在其他被归类为 RIS 的受试者中更早地发现脱髓鞘疾病的存在并做出 MS 诊断。
