Arej Nicolas, Irani Carla, Abdelmassih Youssef, Slim Elise, Antoun Joelle, Bejjani Riad, Schakal Alexandre, Waked Naji
Department of Ophthalmology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.
Hôtel-Dieu de France Hospital, Blvd. Alfred Naccache, Achrafieh, P.O. Box: 166830, Beirut, Lebanon.
Int Ophthalmol. 2018 Oct;38(5):2041-2051. doi: 10.1007/s10792-017-0696-y. Epub 2017 Aug 22.
To describe the profile of patients with allergic conjunctivitis (AC) regarding their demographics, symptomatology and specific allergen sensitization, in a Lebanese tertiary hospital.
Cross-sectional study conducted at the Hôtel-Dieu de France hospital (Beirut, Lebanon) during a period of 18 months. Patients with seasonal or perennial AC presenting for ophthalmic consultation had measurements of total and specific IgE. A matching group of patients with AC seen at the allergist office during the same period underwent skin prick tests (SPTs).
Forty-four patients were enrolled for blood work by their ophthalmologists. Seasonal and perennial forms were almost equivalent. In total, 56.8% had positive specific IgE, with higher prevalence in patients with seasonal AC (p = 0.002), other associated allergies particularly allergic rhinitis (p = 0.002) or a family history of allergy (p = 0.005). Ocular surface severity scales were not shown as predictors. High levels of total IgE were commonly detected in those with positive specific IgE. Thirty-eight patients were assessed with SPT, and all had a positive result for at least one allergen. Dust mites were found to be the most frequent allergens based upon both specific IgE (72%) and SPT (92%), followed by Parietaria and other pollens.
In our study, dust mites mono- or co-sensitization is present in the majority of patients with AC, with odds of positivity being higher using SPT than specific IgE. The latter are found more readily in seasonal AC and in the presence of personal and family history of allergy.
在黎巴嫩一家三级医院中，描述过敏性结膜炎（AC）患者在人口统计学、症状学及特定过敏原致敏方面的情况。
在法国主宫医院（黎巴嫩贝鲁特）进行了为期18个月的横断面研究。前来眼科就诊的季节性或常年性AC患者检测了总IgE和特异性IgE。同期在过敏科就诊的一组匹配的AC患者接受了皮肤点刺试验（SPT）。
44名患者由眼科医生纳入血液检测。季节性和常年性形式几乎相当。总体而言，56.8%的患者特异性IgE呈阳性，在季节性AC患者中患病率更高（p = 0.002），其他相关过敏尤其是过敏性鼻炎（p = 0.002）或有过敏家族史（p = 0.005）。眼表严重程度量表未显示为预测指标。特异性IgE阳性者中普遍检测到高水平的总IgE。38名患者接受了SPT评估，所有患者至少对一种过敏原检测结果呈阳性。基于特异性IgE（72%）和SPT（92%），发现尘螨是最常见的过敏原，其次是墙草属植物和其他花粉。
在我们的研究中，大多数AC患者存在尘螨单一或共同致敏，使用SPT检测阳性的几率高于特异性IgE。后者在季节性AC以及有个人和家族过敏史的患者中更容易发现。
