Salzman C
J Clin Psychiatry. 1987 May;48 Suppl:19-22.
Research studies and general literature support the careful use of neuroleptics for control of agitation-related symptoms in the elderly if the symptoms are severe enough to disrupt normal functioning. No one neuroleptic has been found to be more effective than others; medication choice should therefore be based on differential toxicity rather than differential therapeutic efficacy. The differences in frequency and intensity of neuroleptic side effects are discussed, and the use of nonneuroleptic agents, including beta blockers, in the treatment of agitation is considered.
研究和一般文献均支持,若老年人与激越相关的症状严重到足以干扰正常功能,则应谨慎使用抗精神病药物来控制这些症状。尚未发现哪种抗精神病药物比其他药物更有效;因此,药物选择应基于毒性差异而非治疗效果差异。文中讨论了抗精神病药物副作用的频率和强度差异,并考虑了使用包括β受体阻滞剂在内的非抗精神病药物来治疗激越。