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治疗躁动的阿尔茨海默病患者。

Treating the agitated Alzheimer patient.

作者信息

Zayas E M, Grossberg G T

机构信息

Department of Psychiatry and Human Behavior, Saint Louis University School of Medicine, MO 63104, USA.

出版信息

J Clin Psychiatry. 1996;57 Suppl 7:46-51; discussion 52-4.

PMID:8690697
Abstract

Dementia is a syndrome that consists of cognitive, psychiatric, and behavioral changes. Studies report from 42% to 62% of nursing home residents and at least 50% of outpatients with dementia exhibit behavioral disturbances. Agitation is a frequent behavioral disturbance associated with dementia. The Omnibus Budget Reconciliation Act (OBRA) regulations have made it imperative that physicians review and be familiar with alternative treatment options. We review and present strategies for the evaluation and treatment of agitation in demented patients.

摘要

痴呆是一种由认知、精神和行为改变组成的综合征。研究报告称,42%至62%的养老院居民以及至少50%的痴呆门诊患者存在行为障碍。激越(烦躁不安)是与痴呆相关的常见行为障碍。《综合预算协调法案》(OBRA)的规定使得医生必须审查并熟悉替代治疗方案。我们回顾并介绍了评估和治疗痴呆患者激越的策略。

相似文献

1
Treating the agitated Alzheimer patient.治疗躁动的阿尔茨海默病患者。
J Clin Psychiatry. 1996;57 Suppl 7:46-51; discussion 52-4.
2
Management of agitation, aggression, and psychosis associated with dementia: a pooled analysis including three randomized, placebo-controlled double-blind trials in nursing home residents treated with risperidone.与痴呆相关的激越、攻击行为和精神病的管理:一项汇总分析,包括三项在接受利培酮治疗的疗养院居民中进行的随机、安慰剂对照双盲试验。
Clin Neurol Neurosurg. 2005 Oct;107(6):497-508. doi: 10.1016/j.clineuro.2005.03.013.
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Factor analysis of the Cohen-Mansfield Agitation Inventory in three large samples of nursing home patients with dementia and behavioral disturbance.对三个患有痴呆症和行为障碍的养老院患者大样本进行科恩-曼斯菲尔德激越量表的因素分析。
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Management of the agitated elderly patient in the nursing home: the role of the atypical antipsychotics.养老院中躁动老年患者的管理:非典型抗精神病药物的作用
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Report on an open-label prospective study of divalproex sodium for the behavioral and psychological symptoms of dementia as monotherapy and in combination with second-generation antipsychotic medication.丙戊酸镁缓释片用于治疗痴呆的行为和心理症状的开放标签前瞻性研究报告:单药治疗及与第二代抗精神病药物联合治疗
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Agitation as a possible expression of generalized anxiety disorder in demented elderly patients: toward a treatment approach.激越作为老年痴呆患者广泛性焦虑障碍的一种可能表现:迈向一种治疗方法。
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A review of anticonvulsants in treating agitated demented elderly patients.抗惊厥药物治疗老年痴呆躁动患者的综述。
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Carbamazepine treatment of agitation in Alzheimer's outpatients refractory to neuroleptics.卡马西平治疗对神经安定药难治的阿尔茨海默病门诊患者的激越症状
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10
Beneficial effects of perospirone on aggressive behavior associated with dementia.
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引用本文的文献

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Am J Alzheimers Dis Other Demen. 2012 Feb;27(1):41-7. doi: 10.1177/1533317512439795.
2
Reduced sodium channel Na(v)1.1 levels in BACE1-null mice.BACE1 基因敲除小鼠钠离子通道 Na(v)1.1 水平降低。
J Biol Chem. 2011 Mar 11;286(10):8106-8116. doi: 10.1074/jbc.M110.134692. Epub 2010 Dec 29.
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Alzheimer's secretases regulate voltage-gated sodium channels.阿尔茨海默病的分泌酶调节电压门控钠离子通道。
Neurosci Lett. 2010 Dec 10;486(2):68-72. doi: 10.1016/j.neulet.2010.08.048. Epub 2010 Sep 15.
4
Recognizing and managing antipsychotic drug treatment side effects in the elderly.认识和处理老年人抗精神病药物治疗的副作用
Prim Care Companion J Clin Psychiatry. 2004;6(Suppl 2):14-9.
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Clinical and economic factors in the treatment of behavioural and psychological symptoms of dementia.痴呆行为和心理症状治疗中的临床与经济因素
Drugs Aging. 2001;18(7):527-50. doi: 10.2165/00002512-200118070-00006.
6
Behavioural problems associated with dementia: the role of newer antipsychotics.与痴呆症相关的行为问题:新型抗精神病药物的作用。
Drugs Aging. 1999 Jan;14(1):41-54. doi: 10.2165/00002512-199914010-00003.