青少年精神分裂症治疗指南的效果：来自中等收入国家的经验教训。
Effectiveness of a treatment guideline for schizophrenia in adolescents: Lessons from a middle-income country.
机构信息
1 Child Psychiatric Hospital Dr. Juan N Navarro, Mexico City, Mexico.
2 Arete Proyectos, Mexico City, Mexico.
出版信息
Aust N Z J Psychiatry. 2018 Feb;52(2):192-199. doi: 10.1177/0004867417726581. Epub 2017 Aug 23.
INTRODUCTION
Treatment guidelines for schizophrenia represent a standard way to manage patients, especially in countries with limited staff resources. However, they have not been compared on their efficacy with treatment as usual, despite adult studies suggesting they can be more effective.
METHODS
Inpatient and outpatient adolescents with schizophrenia were randomly allocated to be either treated according to a guideline-based treatment ( n = 43) or treatment as usual ( n = 44). The effects on symptoms, psychosocial functioning and cognition were compared in a 6-month follow-up.
RESULTS
There were no differences between groups in the pharmacological treatment, reduction in symptom severity or cognition. The guideline-based treatment group showed a better functioning at months 3 and 6.
CONCLUSION
The guideline-based treatment had a greater effect than the treatment as usual in the psychosocial functioning of adolescent patients ( www.clinicaltrials.gov ; II3/02/0811).
简介
精神分裂症的治疗指南代表了一种管理患者的标准方法，尤其是在人员资源有限的国家。然而，尽管成人研究表明它们可能更有效，但它们并没有与常规治疗进行疗效比较。
方法
将住院和门诊的青少年精神分裂症患者随机分配接受基于指南的治疗（n=43）或常规治疗（n=44）。在 6 个月的随访中，比较了症状、社会心理功能和认知方面的影响。
结果
两组在药物治疗、症状严重程度或认知方面没有差异。基于指南的治疗组在第 3 个月和第 6 个月的功能表现更好。
结论
基于指南的治疗在青少年患者的社会心理功能方面比常规治疗有更大的效果（www.clinicaltrials.gov；II3/02/0811）。
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