Victoria Gamaliel, Apiquian Rogelio, Rosetti Marcos F, Ulloa Rosa-Elena
Arete Proyectos, Mexico City, Mexico.
Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico.
Schizophr Res Cogn. 2019 Mar 26;17:100135. doi: 10.1016/j.scog.2019.100135. eCollection 2019 Sep.
Studies evaluating the cognitive impairment in schizophrenic adolescents reported a variable course following antipsychotic treatment, with improvement being associated to patients' demographic or clinical characteristics.
To examine the cognitive impairments of a Mexican sample of adolescents with schizophrenia using the MATRICS Consensus Cognitive Battery (MCCB) before and after six months of antipsychotic treatment and to determine which demographic or clinical characteristics could be associated to cognitive improvement.
A sample of 87 Mexican patients was evaluated with the MCCB. Domain scores for three age groups (12-13, 14-15 and 16-17 y.o.) were obtained at baseline, and after 3 and 6 months of treatment. The groups were compared for demographic and clinical variables (sex, school attendance, years of education, being on their first psychotic episode, duration of illness and mean dose of antipsychotic), and a logistic regression analysis was performed to determine which variables predicted larger improvement.
The baseline performance showed scores below the standardized mean, with improvement in all domains except for social cognition; female adolescents showed a larger improvement in attention/vigilance and visual learning domains.
We observed cognitive impairments on schizophrenic adolescents, which improved after six months of treatment in almost all domains.
评估精神分裂症青少年认知障碍的研究报告称，抗精神病药物治疗后的病程变化不定，改善情况与患者的人口统计学或临床特征相关。
使用MATRICS共识认知成套测验（MCCB），在抗精神病药物治疗6个月前后，对一组墨西哥精神分裂症青少年样本的认知障碍进行检查，并确定哪些人口统计学或临床特征可能与认知改善相关。
对87名墨西哥患者样本进行MCCB评估。在基线时以及治疗3个月和6个月后，获取三个年龄组（12 - 13岁、14 - 15岁和16 - 17岁）的领域得分。比较各年龄组的人口统计学和临床变量（性别、上学情况、受教育年限、首次精神病发作、病程和抗精神病药物平均剂量），并进行逻辑回归分析以确定哪些变量可预测更大程度的改善。
基线表现显示得分低于标准化均值，除社会认知外所有领域均有改善；女性青少年在注意力/警觉性和视觉学习领域的改善更大。
我们观察到精神分裂症青少年存在认知障碍，治疗6个月后几乎所有领域的认知障碍均有所改善。
