乙型肝炎病毒暴露与动脉粥样硬化相关发病率增加的关系——一项荟萃分析。
The relationship between exposure to hepatitis B virus and increased atherosclerosis-associated morbidity - a meta-analysis.
机构信息
Department of Neurology, Guangdong Key Laboratory for Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department, National Key Discipline, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Department of Neurology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China
出版信息
Kardiol Pol. 2018;76(1):119-124. doi: 10.5603/KP.a2017.0165. Epub 2017 Aug 23.
BACKGROUND AND AIM
The relationship between exposure to hepatitis B virus (HBV) and atherosclerosis-associated disease morbidity has not been clearly elucidated. We performed a meta-analysis to explore whether exposure to HBV is a risk factor for atherosclerosis-associated diseases.
METHODS
We searched the PubMed, Web of Science, Cochrane Library, Embase, and Scopus databases for related studies. We then chose the eligible studies for meta-analysis and assessed quality assessment and risk of bias.
RESULTS
The meta-analysis of the included studies showed that exposure to HBV tends to increase atherosclerosis-associated disease morbidity, but this increase was not statistically significant.
CONCLUSIONS
Hepatitis B virus may not be a risk factor for atherosclerosis-associated diseases, but further studies that employ more sensitive clinical parameters are needed to verify this result.
背景与目的
乙型肝炎病毒（HBV）暴露与动脉粥样硬化相关疾病发病率之间的关系尚未明确。我们进行了一项荟萃分析，以探讨 HBV 暴露是否是动脉粥样硬化相关疾病的危险因素。
方法
我们检索了 PubMed、Web of Science、Cochrane 图书馆、Embase 和 Scopus 数据库中的相关研究。然后，我们选择了符合条件的研究进行荟萃分析，并评估了质量评估和偏倚风险。
结果
纳入研究的荟萃分析表明，HBV 暴露倾向于增加动脉粥样硬化相关疾病的发病率，但这种增加没有统计学意义。
结论
乙型肝炎病毒可能不是动脉粥样硬化相关疾病的危险因素，但需要进一步研究采用更敏感的临床参数来验证这一结果。
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