Department of Biochemistry and Molecular Biology, University of South China, Hengyang, 421001, Hunan Province, China.
International College, University of South China, Hunan Province, Hengyang, 421001, China.
Mol Cell Biochem. 2021 Aug;476(8):3065-3078. doi: 10.1007/s11010-020-04037-6. Epub 2021 Apr 3.
Vascular diseases (VDs) including pulmonary arterial hypertension (PAH), atherosclerosis (AS) and coronary arterial diseases (CADs) contribute to the higher morbidity and mortality worldwide. Apolipoprotein A-I (Apo A-I) binding protein (AIBP) and Apo-AI negatively correlate with VDs. However, the mechanism by which AIBP and apo-AI regulate VDs still remains unexplained. Here, we provide an overview of the role of AIBP and apo-AI regulation of vascular diseases molecular mechanisms such as vascular energy homeostasis imbalance, oxidative and endoplasmic reticulum stress and inflammation in VDs. In addition, the role of AIBP and apo-AI in endothelial cells (ECs), vascular smooth muscle (VSMCs) and immune cells activation in the pathogenesis of VDs are explained. The in-depth understanding of AIBP and apo-AI function in the vascular system may lead to the discovery of VDs therapy.
血管疾病（VDs）包括肺动脉高压（PAH）、动脉粥样硬化（AS）和冠状动脉疾病（CADs），导致全球更高的发病率和死亡率。载脂蛋白 A-I（Apo A-I）结合蛋白（AIBP）和 Apo-AI 与 VDs 呈负相关。然而，AIBP 和 apo-AI 调节 VDs 的机制仍不清楚。在这里，我们概述了 AIBP 和 apo-AI 调节血管疾病的分子机制，如血管能量平衡失衡、氧化和内质网应激以及炎症在 VDs 中的作用。此外，还解释了 AIBP 和 apo-AI 在血管疾病发病机制中对内皮细胞（ECs）、血管平滑肌（VSMCs）和免疫细胞激活的作用。深入了解 AIBP 和 apo-AI 在血管系统中的功能可能会导致发现 VDs 的治疗方法。
