Thränhardt H, Zintl F, Milleck J, Plenert W
Arch Geschwulstforsch. 1978;48(8):750-5.
An antiserum against human foetal liver cells reacted in in-vitro-cytotoxic test with the leukaemia cells of 6 out of 10 children with acute lymphocytic leukaemias (ALL) and with the lymphoma cells of 1 out 2 children with lymphosarcoma (LS). No cytotoxic reactions were obtained against leukaemia cells of 5 children with acute myelogenic leukaemia (AML), leukaemia cells of 7 adults with chronic lymphocytic leukaemia (CLL), bone marrow cells of 9 children in clinical remission and lymphocytes of normal donors. The cytotoxic activity of the anti-foetalserum was removed by absorption with foetal liver but not with adult liver. The results suggest that foetal antigens may occur on ALL-cells and LS-cells.
一种针对人胎儿肝细胞的抗血清，在体外细胞毒性试验中，与10例急性淋巴细胞白血病（ALL）患儿中的6例白血病细胞以及2例淋巴肉瘤（LS）患儿中的1例淋巴瘤细胞发生反应。对5例急性髓细胞白血病（AML）患儿的白血病细胞、7例慢性淋巴细胞白血病（CLL）成人患者的白血病细胞、9例处于临床缓解期儿童的骨髓细胞以及正常供体的淋巴细胞均未产生细胞毒性反应。抗胎儿血清的细胞毒性活性可通过与胎儿肝脏吸收而去除，但与成人肝脏吸收则不能。结果表明，胎儿抗原可能出现在ALL细胞和LS细胞上。
