Department of Chemistry, Kyungpook National University , Daegu 41566, Republic of Korea.
Oil and POPs Research Group, Korea Institute of Ocean Science and Technology , Geoje 53201, Republic of Korea.
Anal Chem. 2017 Sep 5;89(17):9056-9061. doi: 10.1021/acs.analchem.7b01733. Epub 2017 Aug 23.
Sensitivity is an important factor determining successful mass spectrometry (MS) analysis of metabolome, protein, drugs, and environmental samples. Currently, nanoelectrospray ionization (ESI) is widely used as a sensitive ionization method. However, application of nano-ESI is limited to polar molecules and there is no atmospheric pressure ionization technique developed that can be used for MS analysis of low- and nonpolar compounds with sensitivity that can match with nano-ESI. Herein, we propose paper spray chemical ionization (PSCI) as an ionization technique that can be used to analyze low- and nonpolar aromatic compounds with high sensitivity. PSCI is based on paper spray ionization utilizing corona discharge phenomenon. PSCI can sensitively and quantitatively detect down to picogram (or femtomole) levels of low- and nonpolar aromatic compounds.
灵敏度是决定代谢组学、蛋白质、药物和环境样品的质谱分析成功的一个重要因素。目前，纳喷雾电离子化（ESI）被广泛用作一种灵敏的离子化方法。然而，纳-ESI 的应用仅限于极性分子，并且尚未开发出可用于对具有与纳-ESI 相匹配的灵敏度的低极性和非极性化合物进行 MS 分析的大气压离子化技术。在此，我们提出纸喷雾化学电离（PSCI）作为一种可用于分析具有高灵敏度的低极性和非极性芳香族化合物的电离技术。PSCI 基于利用电晕放电现象的纸喷雾离子化。PSCI 可以灵敏和定量地检测低至皮克（或飞摩尔）级别的低极性和非极性芳香族化合物。
