Zhou Joris, Tholomier Côme, Zanaty Marc, Hueber Pierre-Alain, Valdivieso Roger, Karakewicz Pierre, Liberman Daniel, Misrai Vincent, Zorn Kevin C
CHUM Section of Urology, Department of Surgery, Université de Montréal, Montreal, Quebec, Canada.
Can J Urol. 2017 Aug;24(4):8922-8931.
This study aims at analyzing the impact of reaching current markers of proficiency on intra and postoperative clinical outcomes of laser vaporization with 180W GreenLight XPS in the treatment of benign prostatic hyperplasia.
A retrospective analysis was conducted on a prospectively collected database of 328 consecutive patients who underwent photoselective vaporization of the prostate (PVP) using Greenlight XPS performed by a single experienced laser surgeon. A logarithmic model was used to evaluate the case number to attain benchmark criteria for durable treatment. We compared clinical outcomes before and after current markers of proficiency, defined as either an energy density of 4kJ/cm³ or a 6 month prostate-specific antigen (PSA) drop of = 50%, were attained.
Energy delivered per prostate volume increased significantly with experience. The published benchmark values of 4kJ/cm³ and 6 month PSA drop of 50% were attained after 190 and 155 cases, respectively. There were no significant differences between groups in intraoperative complications or postoperative functional outcomes. However, the number of Clavien-Dindo category I adverse events significantly decreased with experience. Sub-analysis evaluating prostate volumes ≤ 80 cm³ and > 80 cm³ demonstrated comparable clinical outcomes before and after technical proficiency.
In our experience, the case volume required to achieve consistent reference values related to durable clinical outcomes and surgical proficiency was > 150 cases. However, desirable clinical outcomes were attained before reaching current markers of proficiency, regardless of preoperative prostate size. This suggests that current thresholds of technical proficiency may not be a good predictor of satisfying clinical outcomes.
本研究旨在分析达到当前熟练程度指标对180W绿激光XPS汽化术治疗良性前列腺增生的术中及术后临床结果的影响。
对一个前瞻性收集的数据库进行回顾性分析,该数据库包含328例连续接受前列腺光选择性汽化术(PVP)的患者,手术由一位经验丰富的激光外科医生使用绿激光XPS完成。采用对数模型评估达到持久治疗基准标准所需的病例数。我们比较了达到当前熟练程度指标(定义为能量密度4kJ/cm³或6个月前列腺特异性抗原(PSA)下降≥50%)前后的临床结果。
随着经验的增加,每前列腺体积输送的能量显著增加。分别在190例和155例手术后达到了已发表的4kJ/cm³和6个月PSA下降50%的基准值。两组在术中并发症或术后功能结果方面无显著差异。然而,Clavien-Dindo I级不良事件的数量随着经验的增加而显著减少。对前列腺体积≤80 cm³和>80 cm³的亚分析显示,技术熟练前后的临床结果相当。
根据我们的经验,要实现与持久临床结果和手术熟练程度相关的一致参考值,所需的病例数>150例。然而,无论术前前列腺大小如何,在达到当前熟练程度指标之前就已获得了理想的临床结果。这表明当前的技术熟练程度阈值可能不是满意临床结果的良好预测指标。