苯并咪唑染料H8208与DNA及聚肌苷酸-聚胞苷酸的结合
The binding of the benzimidazole dye H8208 to DNA and to polyinosinic-polycytidylic acid.
作者信息
Bardsley H J, Sharples D, Grèzes J R
出版信息
J Pharm Pharmacol. 1987 Mar;39(3):212-4. doi: 10.1111/j.2042-7158.1987.tb06250.x.
Abstract
The benzimidazole dye H8208 (2-(4-aminophenyl)-5-(4-methylpiperazin-1-yl) benzimidazole) has been shown to intercalate into calf thymus DNA and into polyinosinic-polycytidylic acid (a model for A conformation DNA) by a variety of spectroscopic techniques. The binding affinity of the dye was found to be similar to both nucleic acids.
摘要
苯并咪唑染料H8208（2-（4-氨基苯基）-5-（4-甲基哌嗪-1-基）苯并咪唑）已通过多种光谱技术被证明可插入小牛胸腺DNA和聚肌苷酸-聚胞苷酸（A构象DNA的模型）中。发现该染料与两种核酸的结合亲和力相似。
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