Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, U.S.A.
Section of Analytical and Functional Biophotonics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, U.S.A.
Br J Dermatol. 2018 Feb;178(2):350-356. doi: 10.1111/bjd.15896. Epub 2018 Jan 3.
Colchicine is a treatment for gout that has been used for more than a millennium. It is the treatment of choice for familial Mediterranean fever and its associated complication, amyloidosis. The 2009 U.S. Food and Drug Administration approval of colchicine as a new drug had research consequences. Recent investigations with large cohorts of patients with gout who have been taking colchicine for years have demonstrated novel applications within oncology, immunology, cardiology and dermatology. Some emerging dermatological uses include the treatment of epidermolysis bullosa acquisita, leucocytoclastic vasculitis, aphthous stomatitis and others. In this work we relate the history and the new horizon of this ancient medicine.
秋水仙碱是一种治疗痛风的药物，已经使用了一千多年。它是家族性地中海热及其相关并发症淀粉样变性的首选治疗方法。2009 年，美国食品和药物管理局批准秋水仙碱作为一种新药，这带来了一些研究方面的结果。最近，对多年来一直服用秋水仙碱的大量痛风患者进行的调查显示，它在肿瘤学、免疫学、心脏病学和皮肤病学等领域有新的应用。一些新兴的皮肤病学用途包括治疗获得性大疱性表皮松解症、白细胞碎裂性血管炎、口疮性口炎等。在这项工作中，我们介绍了这种古老药物的历史和新的前景。
