Sullivan T P, King L E, Boyd A S
Department of Internal Medicine, Mt. Sinai Medical Center, Miami, Florida, USA.
J Am Acad Dermatol. 1998 Dec;39(6):993-9. doi: 10.1016/s0190-9622(98)70275-0.
Colchicine is a medication most often used to treat symptoms of gout. This drug has also been shown to have beneficial effects on cutaneous conditions, including leukocytoclastic vasculitis, psoriasis, and Sweet's syndrome. Colchicine inhibits the function of polymorphonuclear leukocytes, and dermatoses with a strong presence of these cells may benefit the most from the administration of this medication. A review of the pharmacology, mechanism of action, and adverse reactions of colchicine is also presented.
秋水仙碱是一种最常用于治疗痛风症状的药物。这种药物还被证明对皮肤疾病有有益作用，包括白细胞破碎性血管炎、银屑病和Sweet综合征。秋水仙碱抑制多形核白细胞的功能，而这些细胞大量存在的皮肤病可能从使用这种药物中获益最大。本文还对秋水仙碱的药理学、作用机制和不良反应进行了综述。
