秋水仙碱：新旧情况
Colchicine: old and new.
作者信息
Slobodnick Anastasia, Shah Binita, Pillinger Michael H, Krasnokutsky Svetlana
机构信息
Department of Medicine, VA New York Harbor Health Care System, New York; Division of Rheumatology, Department of Medicine, NYU School of Medicine/NYU Langone Medical Center, New York.
Department of Medicine, VA New York Harbor Health Care System, New York; Division of Cardiology, Department of Medicine, NYU School of Medicine/NYU Langone Medical Center, New York.
出版信息
Am J Med. 2015 May;128(5):461-70. doi: 10.1016/j.amjmed.2014.12.010. Epub 2014 Dec 30.
Abstract
Although colchicine has been a focus of research, debate, and controversy for thousands of years, the US Food and Drug Administration just approved it in 2009. Over the past decade, advances in the knowledge of colchicine pharmacology, drug safety, and mechanisms of action have led to changes in colchicine dosing and to potential new uses for this very old drug. In this review, we discuss the pharmacologic properties of colchicine and summarize what is currently known about its mechanisms of action. We then discuss and update the use of colchicine in a variety of illnesses, including rheumatic and, most recently, cardiovascular diseases.
摘要
尽管秋水仙碱数千年来一直是研究、争论和争议的焦点，但美国食品药品监督管理局直到2009年才批准它。在过去十年中，秋水仙碱药理学、药物安全性及作用机制方面的知识进展，已导致秋水仙碱给药剂量的改变以及这种古老药物潜在的新用途。在本综述中，我们讨论秋水仙碱的药理学特性，并总结目前已知的其作用机制。然后，我们讨论并更新秋水仙碱在多种疾病中的应用，包括风湿性疾病以及最近的心血管疾病。
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本文引用的文献
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Colchicine for prevention of postpericardiotomy syndrome and postoperative atrial fibrillation: the COPPS-2 randomized clinical trial.秋水仙碱预防心包切开术后综合征和术后心房颤动：COPPS-2 随机临床试验。
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Colchicine-Induced Myopathy in a Tacrolimus-Treated Renal Transplant Recipient: Case Report and Literature Review.他克莫司治疗的肾移植受者中，秋水仙碱诱发的肌病：病例报告及文献综述
Am J Ther. 2016 Mar-Apr;23(2):e614-6. doi: 10.1097/MJT.0000000000000044.
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Acute colchicine overdose: report of three cases.急性秋水仙碱过量：三例报告。
Reumatismo. 2014 Mar 17;65(6):307-11. doi: 10.4081/reumatismo.2013.720.
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Colchicine for treatment of acute or recurrent pericarditis.秋水仙碱用于治疗急性或复发性心包炎。
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Efficacy and safety of colchicine for treatment of multiple recurrences of pericarditis (CORP-2): a multicentre, double-blind, placebo-controlled, randomised trial.秋水仙碱治疗多发性心包炎复发的疗效和安全性（CORP-2）：一项多中心、双盲、安慰剂对照、随机试验。
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Familial mediterranean fever: a fascinating model of inherited autoinflammatory disorder.家族性地中海热：遗传性自身炎症性疾病的迷人模型。
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A case of hypocomplementaemic urticarial vasculitis with a high serum level of rheumatoid factor.一例低补体血症性荨麻疹性血管炎伴高滴度类风湿因子。
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