Udomsangpetch R, Todd J, Carlson J, Greenwood B M
Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Am J Trop Med Hyg. 1993 Feb;48(2):149-53. doi: 10.4269/ajtmh.1993.48.149.
The mechanisms by which the hemoglobin genotype AS protect against severe malaria are not fully understood. We have investigated the possibility that protection might be achieved through an inability of red blood cells (RBC) with the AS genotype to form rosettes with RBC infected by Plasmodium falciparum. No evidence was obtained to support this hypothesis because RBC with the AS genotype formed rosettes with wild isolates of P. falciparum as readily as RBC with the AA genotype. However, the previous finding that parasitized RBC form rosettes more readily with RBC belonging to group A or B than with RBC belonging to group O was confirmed even in fresh clinical isolates.
血红蛋白基因型AS预防重症疟疾的机制尚未完全明确。我们研究了一种可能性，即AS基因型的红细胞无法与感染恶性疟原虫的红细胞形成花结，从而实现预防作用。但未获得证据支持这一假设，因为AS基因型的红细胞与AA基因型的红细胞一样，都能轻易地与恶性疟原虫的野生分离株形成花结。然而，之前的研究发现，即使在新鲜的临床分离株中，被寄生的红细胞与A组或B组红细胞形成花结的可能性也高于与O组红细胞。
