尼扎替丁作为一种用于检测消化性溃疡疾病的新型高选择性放射性示踪剂的放射性碘化及生物学评价。
Radioiodination and biological evaluation of nizatidine as a new highly selective radiotracer for peptic ulcer disorder detection.
作者信息
Sanad M H, Saleh Gehan M, Marzook F A
机构信息
Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division, Hot Laboratories Center, Atomic Energy Authority, Cairo, Egypt.
Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.
出版信息
J Labelled Comp Radiopharm. 2017 Nov;60(13):600-607. doi: 10.1002/jlcr.3541. Epub 2017 Oct 6.
Nizatidine has been labeled using [ I] with chloramine-T as oxidizing agent. Factors such as the amount of oxidizing agent, amount of substrate, pH, reaction temperature, and reaction time have been systematically studied to optimize the iodination. Biodistribution studies indicate the suitability of radioiodinated nizatidine as a novel tracer to image stomach ulcer. Radioiodinated nizatidine may be considered a highly selective radiotracer for peptic ulcer imaging.
已使用氯胺 -T作为氧化剂，用[I]对尼扎替丁进行标记。已系统研究了诸如氧化剂用量、底物用量、pH值、反应温度和反应时间等因素，以优化碘化反应。生物分布研究表明，放射性碘化尼扎替丁适合作为一种新型示踪剂用于胃溃疡成像。放射性碘化尼扎替丁可被视为用于消化性溃疡成像的高选择性放射性示踪剂。
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