隔日注射生长激素时发生低血糖的风险。
Risk of hypoglycaemia with alternate-day growth hormone injections.
作者信息
Press M, Notarfrancesco A, Genel M
出版信息
Lancet. 1987 May 2;1(8540):1002-4. doi: 10.1016/s0140-6736(87)92270-7.
PMID:2883344
Abstract
Fasting hypoglycaemia developed in three growth hormone deficient children after the start of treatment with synthetic growth hormone. The effects, which occurred 36-60 h after each injection, may have been due to insulin-like effects of endogenous somatomedins after waning of insulin antagonism induced by growth hormone. Daily growth hormone injections may be necessary to maintain normal plasma glucose levels in young children.
摘要
三名生长激素缺乏的儿童在开始使用合成生长激素治疗后出现了空腹低血糖。这些效应在每次注射后36 - 60小时出现，可能是由于生长激素诱导的胰岛素拮抗作用减弱后内源性生长调节素的胰岛素样效应所致。对于幼儿，可能需要每日注射生长激素以维持正常的血浆葡萄糖水平。
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