Boersma B, Rikken B, Wit J M
Department of Paediatrics, University Hospital Leiden, The Netherlands.
Arch Dis Child. 1995 May;72(5):427-31. doi: 10.1136/adc.72.5.427.
Catch-up growth of 26 children with growth hormone deficiency during four years of growth hormone treatment, which was started young (< 3 years), was compared with that of 16 children with coeliac disease on a gluten free diet. In children with growth hormone deficiency mean (SD) height SD score increased from -4.3 (1.8) to -1.9 (1.4) and in patients with coeliac disease from -1.8 (0.9) to -0.1 (0.8). Height SD score after four years correlated positively with injection frequency and height SD score at start of treatment in children with growth hormone deficiency. All patients with coeliac disease reached a height above -2 SD scores after four years, while the height of 26% of children with growth hormone deficiency on daily injections and of 86% of children on 2 or 4 injections/week was still below -2 SD scores. In patients with growth hormone deficiency on daily injections with an initial height SD score between -2 and -4 catch-up was similar to that of patients with coeliac disease with a comparable initial height deficit. Growth hormone deficient children with an initial height SD score < -4 did not reach full catch-up growth within four years. In conclusion, catch-up growth in early treated children with growth hormone deficiency over four years is adequate provided that daily injections are given and the initial height SD score is not less than -4.
对26名幼年（<3岁）开始接受生长激素治疗的生长激素缺乏儿童在四年生长激素治疗期间的追赶生长情况，与16名采用无麸质饮食的乳糜泻儿童的追赶生长情况进行了比较。生长激素缺乏儿童的平均（标准差）身高标准差评分从-4.3（1.8）增至-1.9（1.4），乳糜泻患者则从-1.8（0.9）增至-0.1（0.8）。生长激素缺乏儿童四年后的身高标准差评分与注射频率及治疗开始时的身高标准差评分呈正相关。所有乳糜泻患者四年后身高均达到高于-2标准差评分，而每日注射生长激素的生长激素缺乏儿童中有26%、每周注射2次或4次的儿童中有86%的身高仍低于-2标准差评分。初始身高标准差评分在-2至-4之间的每日注射生长激素的生长激素缺乏患者的追赶生长情况与初始身高缺陷相当的乳糜泻患者相似。初始身高标准差评分<-4的生长激素缺乏儿童在四年内未实现完全追赶生长。总之，对于早期接受治疗的生长激素缺乏儿童，若每日进行注射且初始身高标准差评分不低于-4，则四年内的追赶生长情况是足够的。
