Hennighausen G, Lange P
Arch Toxicol Suppl. 1979(2):315-20. doi: 10.1007/978-3-642-67265-1_29.
The effects of di-n-octyltin dichloride (DOTC) on the thymus in mice were studied in dependence on the route of administration. Single administrations of 30, 60 and 120 mg/kg of DOTC i.m. induced a dose-related decrease of the thymus weight and of the number of nucleated cells in the thymus of male mice. 4 days after intravenous injection of 8 mg/kg of DOTC the thymus weight and the number of thymocytes were reduced to 50 percent of the control. In oral route of administration higher doses of DOTC (300 mg/kg) were necessary to provoke a thymus atrophy. After pretreatment of mice with carbon tetrachloride the toxic effects of orally administered DOTC were increased. The reduction of the thymus weight and of the number of thymocytes in mice after parenteral administration was accompanied by a depression of thymus-dependent antibody formation against sheep red blood cells.
研究了二正辛基二氯化锡（DOTC）对小鼠胸腺的影响，并探讨了给药途径的依赖性。雄性小鼠肌肉注射30、60和120mg/kg的DOTC单次给药，可导致胸腺重量和胸腺中有核细胞数量呈剂量依赖性下降。静脉注射8mg/kg的DOTC 4天后，胸腺重量和胸腺细胞数量降至对照组的50%。口服给药途径需要更高剂量的DOTC（300mg/kg）才能引发胸腺萎缩。用四氯化碳预处理小鼠后，口服DOTC的毒性作用增强。经肠胃外给药后，小鼠胸腺重量和胸腺细胞数量的减少伴随着针对绵羊红细胞的胸腺依赖性抗体形成的抑制。
