亚急性吸入甲苯对大鼠体内其代谢及处置的影响。
Effects of subacute toluene inhalation on its metabolism and disposition in rat.
作者信息
Elovaara E, Savolainen H, Pfäffli P, Vainio H
出版信息
Arch Toxicol Suppl. 1979(2):345-8. doi: 10.1007/978-3-642-67265-1_34.
PMID:288342
Abstract
Exposure of adult male rats to 300 ppm of toluene for 1 to 15 weeks 6 h daily caused accumulation of the solvent in brain and in perirenal fat. The body solvent content tended to decrease during extended exposure which might be explained by the enhanced activity of drug-metabolizing enzymes in liver. Our findings also indicate that metabolic and functional adaptation takes place in longer exposures to low levels of toluene vapour.
摘要
成年雄性大鼠每天暴露于300 ppm甲苯中6小时，持续1至15周，会导致该溶剂在大脑和肾周脂肪中蓄积。在延长暴露期间，体内溶剂含量趋于下降，这可能是由于肝脏中药物代谢酶活性增强所致。我们的研究结果还表明，在长期暴露于低水平甲苯蒸气的情况下会发生代谢和功能适应。
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