Elovaara E, Pfäffli P, Savolainen H
Acta Pharmacol Toxicol (Copenh). 1984 Oct;55(4):283-6. doi: 10.1111/j.1600-0773.1984.tb01983.x.
Male Wistar rats exposed intermittently to cyclopentanone vapour at 50, 100 or 300 p.p.m. 6 hrs daily 5 days a week for 1 to 15 weeks showed brain and perirenal fat solvent concentrations which correlated to the exposure although they decreased at the later stages of the experiment. Cyclopentanone caused almost no effects on liver drug metabolizing enzymes or aldehyde dehydrogenase activities while an early increase in the kidney 7-ethoxycoumarin O-deethylase was found after 1 week without a concomitant increase in the cytochrome P-450 content. This effect was abolished later so that an enhancement was found only at the highest exposure level after 15 weeks. Postmitochondrial fractions isolated from liver of exposed animals metabolized cyclopentanone more actively than controls after 15 weeks.
雄性Wistar大鼠每周5天、每天6小时间歇性暴露于浓度为50、100或300 ppm的环戊酮蒸汽中，持续1至15周。结果显示，尽管在实验后期脑和肾周脂肪中的溶剂浓度有所下降，但它们与暴露量相关。环戊酮对肝脏药物代谢酶或醛脱氢酶活性几乎没有影响，而在第1周时发现肾脏7 - 乙氧基香豆素O - 脱乙基酶早期增加，同时细胞色素P - 450含量并未随之增加。这种效应在后期消失，因此仅在15周后最高暴露水平时发现有增强。15周后，从暴露动物肝脏分离的线粒体后组分比对照组更活跃地代谢环戊酮。
