Caterini J E, Banks L, Wells G D, Cifra B, Slorach C, McCrindle B W, Seed M
Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, Canada.
Labatt Family Heart Centre, Hospital for Sick Children, Toronto, Canada.
Clin Obes. 2017 Dec;7(6):360-367. doi: 10.1111/cob.12206. Epub 2017 Aug 23.
The aortic pulse wave velocity (PWV) measured via cardiac magnetic resonance (CMR) can be used to non-invasively assess changes in arterial stiffness and potential underlying vascular dysfunction. This technique could unmask early arterial dysfunction in overweight and obese youth at risk for cardiovascular disease. We sought to determine the association between vascular stiffness, percentage body fat, body mass index (BMI), and cardiac function in adolescents across the weight spectrum through both CMR and standard applanation tonometry (AT)-based PWV measurements. PWV and left-ventricular cardiac function were assessed using 3.0 T CMR in obese and overweight (OB/OW) participants (n = 12) and controls (n = 7). PWV was also estimated via carotid-femoral AT. OB/OW participants did not differ from healthy-weight controls regarding cardiometabolic risk factors or physical activity levels, but there was a trend towards higher levels of triglycerides in obese/overweight participants (P = 0.07). Mean PWV was higher in obese participants when corrected for age and sex (P = 0.01), and was positively associated with BMI (β = 0.51, P = 0.02). PWV estimated through AT was not significantly different between groups. Cardiac function measured by left-ventricular ejection fraction z-score was inversely associated with mean PWV (β = -0.57, P = 0.026). Increasing arterial stiffness and decreasing cardiac function were evident among our overweight and obese cohort. PWV estimated by CMR could detect early increases in arterial stiffness vs. traditional AT measurements of PWV.
通过心脏磁共振成像（CMR）测量的主动脉脉搏波速度（PWV）可用于无创评估动脉僵硬度的变化以及潜在的基础血管功能障碍。该技术可揭示有心血管疾病风险的超重和肥胖青少年的早期动脉功能障碍。我们试图通过CMR和基于标准压平式眼压测量法（AT）的PWV测量来确定不同体重范围的青少年血管僵硬度、体脂百分比、体重指数（BMI）与心脏功能之间的关联。使用3.0T CMR对肥胖和超重（OB/OW）参与者（n = 12）和对照组（n = 7）进行PWV和左心室心脏功能评估。还通过颈股AT估计PWV。OB/OW参与者在心血管代谢危险因素或身体活动水平方面与健康体重对照组无差异，但肥胖/超重参与者的甘油三酯水平有升高趋势（P = 0.07）。校正年龄和性别后，肥胖参与者的平均PWV较高（P = 0.01），且与BMI呈正相关（β = 0.51，P = 0.02）。两组之间通过AT估计的PWV无显著差异。通过左心室射血分数z评分测量的心脏功能与平均PWV呈负相关（β = -0.57，P = 0.026）。在我们的超重和肥胖队列中，动脉僵硬度增加和心脏功能下降很明显。与传统的AT测量PWV相比，CMR估计的PWV可以检测到动脉僵硬度的早期增加。
