Yi Elizabeth M, Leech Elizabeth
VCA Emergency Animal Hospital and Referral Center, San Diego, CA, 92108.
J Vet Emerg Crit Care (San Antonio). 2017 Nov;27(6):707-712. doi: 10.1111/vec.12638. Epub 2017 Aug 23.
To describe the clinical presentation and treatment of a cat with flurbiprofen toxicosis due to topical cream exposure.
A 3-year-old castrated male domestic shorthair cat presented to an emergency and referral center for acute lethargy, hematemesis, and anemia. Severe azotemia was observed on serum biochemistry panel. The patient's anemia was treated with packed RBC transfusion, and treatment with crystalloid fluids, famotidine, pantoprazole, ampicillin, and sucralfate were begun on presentation. Anemia became intractable and the patient received multiple packed RBC and whole blood transfusions. Severe gastric ulcerations and duodenal perforation were confirmed via gastroduodenoscopy, and the patient was treated with surgical excision and repair of duodenal perforation. Azotemia resolved with IV fluid therapy, and anemia resolved following surgery. The patient recovered and was discharged after 9 days of hospitalization. The patient had likely been exposed to the owner's compounded pain relief cream containing 10% flurbiprofen. There was confirmation of flurbiprofen exposure via acid extraction urine analysis at a university toxicology laboratory.
This is the first described case of flurbiprofen toxicosis due to topical cream exposure in a cat.
描述一只因接触外用乳膏而发生氟比洛芬中毒的猫的临床表现及治疗情况。
一只3岁去势雄性家养短毛猫因急性嗜睡、呕血和贫血被送至一家急诊及转诊中心。血清生化检查显示严重氮质血症。患者的贫血通过输注浓缩红细胞进行治疗，就诊时即开始使用晶体液、法莫替丁、泮托拉唑、氨苄西林和硫糖铝进行治疗。贫血变得难以控制，患者接受了多次浓缩红细胞和全血输注。通过胃十二指肠镜检查确诊为严重胃溃疡和十二指肠穿孔，患者接受了十二指肠穿孔的手术切除和修复治疗。氮质血症通过静脉输液治疗得以缓解，贫血在手术后得到缓解。患者康复，住院9天后出院。该患者可能接触了主人配制的含10%氟比洛芬的止痛乳膏。通过大学毒理学实验室的酸提取尿液分析证实了氟比洛芬暴露。
这是首例描述的猫因接触外用乳膏而发生氟比洛芬中毒的病例。
