Gürtler J, Donatsch P
Arch Toxicol Suppl. 1979(2):381-5. doi: 10.1007/978-3-642-67265-1_42.
The influence of two drugs with antispermatogenic properties on steroid biosynthesis has been studied in rat testes in vitro with pregnenolone as the substrate. 20-438, an indenopyridine derivative increased the relative conversion of pregnenolone to progestins and estradiol, whilst decreasing the conversion of substrate to testosterone and androstenedione. PMHI, a pipecolinoindane derivative, reduced testosterone levels in the testes without altering the relative conversion of pregnenolone to various steroids. This suggests that the agent is partially inhibiting the biosynthesis of androgen precursors leading to a testosterone deficiency in testicular tissue which may result in reduced spermatogenesis.
以孕烯醇酮为底物，在体外对大鼠睾丸研究了两种具有抗生精特性的药物对类固醇生物合成的影响。20-438，一种茚并吡啶衍生物，增加了孕烯醇酮向孕激素和雌二醇的相对转化率，同时降低了底物向睾酮和雄烯二酮的转化率。PMHI，一种哌啶并茚满衍生物，降低了睾丸中的睾酮水平，而不改变孕烯醇酮向各种类固醇的相对转化率。这表明该药物部分抑制雄激素前体的生物合成，导致睾丸组织中睾酮缺乏，这可能会导致精子发生减少。
