Kinson G A
Arch Androl. 1978;1(2):185-91. doi: 10.3109/01485017808988336.
Mature and young adult rats were treated with a single dose of 115 mg and 50 mg of pipecolinomethylhydroxyindane (PMHI) maleate per kg of body weight. Large intraperitoneal doses were toxic in mature rats and the growth of younger animals were retarded by the lower subcutaneous dose. In both instances, PMHI caused a rapid reduction in testis weight with arrested spermatogenesis. Atrophic changes to the ventral prostrate and the lowering of blood testosterone levels suggests that the actions of PMHI are not strictly confined to the seminiferous tubules. This was further substantiated by the demonstration of direct inhibition by PMHI of testicular androgenesis in vitro. The actions of PMHI on steroidogenesis may be readily reversible and, compared to tubular actions, are of a minor nature. There were no clear-cut adrenocortical responses to PMHI administration but there was some depression of adrenal gland weight, plasma corticosterone, and aldosterone.
对成年和幼年大鼠分别按每千克体重115毫克和50毫克的剂量单次给予马来酸哌啶甲基羟基茚满（PMHI）。大剂量腹腔注射对成年大鼠有毒性，而较低剂量皮下注射则会阻碍幼年动物的生长。在这两种情况下，PMHI都会导致睾丸重量迅速减轻，精子发生停滞。腹侧前列腺的萎缩变化以及血液睾酮水平的降低表明，PMHI的作用并不严格局限于生精小管。PMHI在体外对睾丸雄激素生成的直接抑制作用进一步证实了这一点。PMHI对类固醇生成的作用可能很容易逆转，与对小管的作用相比，其性质较为轻微。给予PMHI后，肾上腺皮质没有明显的反应，但肾上腺重量、血浆皮质酮和醛固酮有一定程度的降低。
