双吡啶盐HGG - 12、HGG - 42以及阿托品、苯那嗪对犬有机磷中毒的治疗作用。
Therapeutic effects of the bis-pyridinium salts HGG-12, HGG-42, and atropine, benactyzine in organophosphate poisoning of dogs.
作者信息
Hauser W, Weger N
出版信息
Arch Toxicol Suppl. 1979(2):393-6. doi: 10.1007/978-3-642-67265-1_44.
PMID:288351
Abstract
Therapeutic properties of various combinations of the bispyridinium salts HGG-12 and HGG-42 against soman and sarin poisoning were investigated in male beagles. Best therapeutic efficiency was shown by HGG-42 in a dosage of 30 muMol/kg. Also good effects were produced by the combination of both oximes in a low dosage of 3 muMol/kg for each one. In soman poisoning no significant reactivation of cholinesterase in serum or erythrocytes was observed.
摘要
在雄性比格犬中研究了双吡啶盐HGG - 12和HGG - 42的各种组合对梭曼和沙林中毒的治疗特性。HGG - 42以30微摩尔/千克的剂量显示出最佳治疗效果。两种肟以每种3微摩尔/千克的低剂量组合也产生了良好效果。在梭曼中毒中，未观察到血清或红细胞中胆碱酯酶的显著重新激活。
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