Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, 100853, China.
Nanlou Medical Oncology Department, Chinese PLA General Hospital, Beijing, 100853, China.
World J Surg Oncol. 2017 Aug 23;15(1):158. doi: 10.1186/s12957-017-1233-1.
The efficacy of exercise training in patients with lung cancer after lung resection has not been well established yet. Therefore, we performed a meta-analysis to investigate the efficiency of exercise training in patients with lung cancer after lung resection.
Several databases were searched for eligible randomised controlled trials (RCTs). The primary outcome was quality of life, and the secondary outcomes included 6-min walk distance (6MWD), forced expiratory volume in 1 s (FEV) and postoperative complications (POCs). Weighted mean differences (WMDs) and relative risks (RRs) with 95% confidence intervals (CIs) were calculated by random-effects model.
Six RCTs involving 438 patients were enrolled in this meta-analysis. The pooled WMDs of the scores were 2.41 (95% CI = -5.20 to 10.02; P = 0.54) and -0.46 (95% CI = -20.52 to 19.61; P = 0.96) for the physical and mental components of the 36-item short-form scale, respectively. The pooled WMDs were 23.50 m (95% CI = -22.04 to 69.03; P = 0.31) for 6MWD and 0.03 L (95% CI = -0.19 to 0.26; P = 0.76) for FEV. Finally, the pooled RRs were 0.79 (95% CI = 0.41 to 1.53; P = 0.49) for POCs.
Insufficient evidence is available to support the efficacy of exercise training in patients with lung cancer after lung resection. Further studies must confirm our findings and investigate the long-term effects of exercise training on patients with lung cancer following lung resection.
肺癌切除术后患者进行运动训练的疗效尚未得到充分证实。因此，我们进行了一项荟萃分析，以调查肺癌切除术后患者运动训练的效果。
检索了多个数据库以寻找符合条件的随机对照试验（RCT）。主要结局是生活质量，次要结局包括 6 分钟步行距离（6MWD）、1 秒用力呼气量（FEV）和术后并发症（POC）。采用随机效应模型计算加权均数差值（WMD）和相对风险（RR）及其 95%置信区间（CI）。
这项荟萃分析纳入了 6 项 RCT，共 438 例患者。两组的 36 项简短健康调查问卷的身体和精神成分评分的合并 WMD 分别为 2.41（95%CI=-5.20 至 10.02；P=0.54）和-0.46（95%CI=-20.52 至 19.61；P=0.96）。6MWD 的合并 WMD 为 23.50m（95%CI=-22.04 至 69.03；P=0.31），FEV 的合并 WMD 为 0.03L（95%CI=-0.19 至 0.26；P=0.76）。最后，POC 的合并 RR 为 0.79（95%CI=0.41 至 1.53；P=0.49）。
尚无充分证据支持肺癌切除术后患者进行运动训练的疗效。需要进一步的研究来证实我们的发现，并探讨运动训练对肺癌切除术后患者的长期影响。
