Omori T, Sugai H, Imai Y, Ishikawa T
School of Engineering, Tohoku University, Japan.
Graduate School of Biomedical Engineering, Tohoku University, Japan.
J Biomech. 2017 Aug 16;61:242-249. doi: 10.1016/j.jbiomech.2017.07.025. Epub 2017 Aug 10.
Cilia-driven nodal flow is important in the determination of left-right asymmetry in the body. Several theoretical and computational models have been proposed to explain the mechanics of ciliary motion, although the full mechanism remains unknown. Here, we developed a three-dimensional nodal cilia axoneme model using a finite element-boundary element coupling method, and investigated the mechanics of nodal ciliary motion. We found that the rotational orbit was strongly dependent on the dynein activation frequency. We also investigated flow field generated by the ciliary rotation, and the flow strength decayed as r at the far field from the cilium. Our numerical results also suggest that experimentally observed tilt angle θ=2π/9 is sufficiently large to make a leftward flow. These findings are helpful in better understanding ciliary motion and nodal flow.
纤毛驱动的节点流对于确定身体的左右不对称性很重要。尽管完整的机制仍然未知，但已经提出了几种理论和计算模型来解释纤毛运动的力学原理。在这里，我们使用有限元-边界元耦合方法开发了一个三维节点纤毛轴丝模型，并研究了节点纤毛运动的力学原理。我们发现旋转轨道强烈依赖于动力蛋白激活频率。我们还研究了纤毛旋转产生的流场，并且在远离纤毛的远场处，流动强度随r衰减。我们的数值结果还表明，实验观察到的倾斜角θ=2π/9足够大，足以产生向左的流动。这些发现有助于更好地理解纤毛运动和节点流。
