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B-cell receptor sequencing of anti-citrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of -glycosylation sites during somatic hypermutation.

作者信息

Vergroesen Rochelle D, Slot Linda M, Hafkenscheid Lise, Koning Marvyn T, van der Voort Ellen I H, Grooff Christine A, Zervakis George, Veelken Hendrik, Huizinga Tom W J, Rispens Theo, Scherer Hans U, Toes René E M

机构信息

Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.

Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.

出版信息

Ann Rheum Dis. 2018 Jun;77(6):956-958. doi: 10.1136/annrheumdis-2017-212052. Epub 2017 Aug 23.

DOI:10.1136/annrheumdis-2017-212052
PMID:28835463
Abstract
摘要

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1
B-cell receptor sequencing of anti-citrullinated protein antibody (ACPA) IgG-expressing B cells indicates a selective advantage for the introduction of -glycosylation sites during somatic hypermutation.表达抗瓜氨酸化蛋白抗体（ACPA）IgG的B细胞的B细胞受体测序表明，在体细胞超突变过程中引入N-糖基化位点具有选择性优势。
Ann Rheum Dis. 2018 Jun;77(6):956-958. doi: 10.1136/annrheumdis-2017-212052. Epub 2017 Aug 23.
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Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis.ACPA-IgG 可变域的广泛糖基化调节与类风湿关节炎中瓜氨酸化抗原的结合。
Ann Rheum Dis. 2016 Mar;75(3):578-85. doi: 10.1136/annrheumdis-2014-206598. Epub 2015 Jan 13.
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-Glycosylation Site Analysis of Citrullinated Antigen-Specific B-Cell Receptors Indicates Alternative Selection Pathways During Autoreactive B-Cell Development.瓜氨酸化抗原特异性 B 细胞受体糖基化位点分析表明自身反应性 B 细胞发育过程中的替代选择途径。
Front Immunol. 2019 Sep 4;10:2092. doi: 10.3389/fimmu.2019.02092. eCollection 2019.
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Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis.鉴定和分析类风湿关节炎患者外周血中瓜氨酸化抗原特异性 B 细胞。
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A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis.类风湿关节炎中不同 IgG 和 IgA 抗修饰蛋白自身抗体关系的综合评价
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Monoclonal antibody against citrullinated peptides obtained from rheumatoid arthritis patients reacts with numerous citrullinated microbial and food proteins.针对来自类风湿关节炎患者的瓜氨酸化肽的单克隆抗体与许多瓜氨酸化的微生物和食物蛋白发生反应。
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Selected cyclic citrullinated peptides derived from the sequence of mutated and citrullinated vimentin (MCV) are targeted by different antibodies subclasses in patients with rheumatoid arthritis in Russian patients.在俄罗斯类风湿关节炎患者中，源自突变和瓜氨酸化波形蛋白（MCV）序列的选定环状瓜氨酸化肽被不同抗体亚类靶向。
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The extensive glycosylation of the ACPA variable domain observed for ACPA-IgG is absent from ACPA-IgM.在ACPA-IgM中未观察到ACPA-IgG所具有的ACPA可变结构域的广泛糖基化。
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