Beato-Víbora Pilar I, Alejo-González S
Department of Endocrinology, Badajoz University Hospital, Badajoz, Spain.
Department of Biochemistry, Badajoz University Hospital, Badajoz, Spain.
Int J Endocrinol Metab. 2016 Nov 14;15(1):e37792. doi: 10.5812/ijem.37792. eCollection 2017 Jan.
Interfering antibodies are capable of causing potentially misleading results in automated thyroid hormone immunoassays.
We report the case of a 46- year-old female patient with autoimmune hypothyroidism in chronic replacement treatment with levothyroxine who was presented 8 years after diagnosis with a thyroid function test showing an increased level of TSH and a very high level of FT4. Interference in the laboratory serum free thyroxin (FT4) test was suspected, due to the lack of symptoms of hyperthyroidism and a different immunoassay platform confirmed a low FT4 result. The discrepancy between the two results was explained by the presence of antiT4-autoantibodies.
Antibody interference with serum free thyroxine must be considered when clinical findings and laboratory results show discrepancies.
干扰性抗体可能会在自动甲状腺激素免疫测定中导致潜在的误导性结果。
我们报告了一例46岁女性自身免疫性甲状腺功能减退患者的病例，该患者长期接受左甲状腺素替代治疗，诊断8年后进行甲状腺功能检查，结果显示促甲状腺激素（TSH）水平升高，游离甲状腺素（FT4）水平极高。由于缺乏甲状腺功能亢进症状，怀疑实验室血清游离甲状腺素（FT4）检测存在干扰，另一个免疫测定平台证实FT4结果较低。两种结果之间的差异是由抗T4自身抗体的存在所解释的。
当临床发现与实验室结果出现差异时，必须考虑抗体对血清游离甲状腺素的干扰。
