Heidari Behzad, Muhammadi Abdollah, Javadian Yahya, Bijani Ali, Hosseini Reza, Babaei Mansour
Mobility Impairment Research Center, Babol University of Medical Sciences, Babol, Iran.
Department of Social Medicine, Babol University of Medical Sciences, Babol, Iran.
Int J Endocrinol Metab. 2016 Nov 27;15(1):e39662. doi: 10.5812/ijem.39662. eCollection 2017 Jan.
Low bone mineral density and osteoporosis is prevalent in elderly subjects. This study aimed to determine the associated factors of bone mineral density and osteoporosis in elderly males.
All participants of the Amirkola health and ageing project cohort aged 60 years and older entered the study. Bone mineral density at femoral neck and lumbar spine was assessed by the dual energy X-ray absorptiometry (DXA) method. Osteoporosis was diagnosed by the international society for clinical densitometry criteria and the association of bone mineral density and osteoporosis with several clinical, demographic and biochemical parameters. Multiple logistic regression analysis was used to determine independent associations.
A total of 553 patients were studied and 90 patients (16.2%) had osteoporosis at either femoral neck or lumbar spine. Diabetes, obesity, metabolic syndrome, overweight, and quadriceps muscle strength > 30 kg, metabolic syndrome, abdominal obesity and education level were associated with higher bone mineral density and lower prevalence of osteoporosis, whereas age, anemia, inhaled corticosteroids and fracture history were associated with lower bone mineral density and higher prevalence of osteoporosis (P = 0.001). After adjustment for all covariates, osteoporosis was negatively associated only with diabetes, obesity, overweight, and QMS > 30 kg and positively associated with anemia and fracture history. The association of osteoporosis with other parameters did not reach a statistical level.
The findings of the study indicate that in elderly males, diabetes, obesity and higher muscle strength was associated with lower prevalence of osteoporosis and anemia, and prior fracture with higher risk of osteoporosis. This issue needs further longitudinal studies.
低骨密度和骨质疏松在老年人群中普遍存在。本研究旨在确定老年男性骨密度和骨质疏松的相关因素。
纳入阿米尔科拉健康与老龄化项目队列中所有60岁及以上的参与者。采用双能X线吸收法（DXA）评估股骨颈和腰椎的骨密度。根据国际临床骨密度测量学会标准诊断骨质疏松，并分析骨密度和骨质疏松与多种临床、人口统计学和生化参数之间的关联。采用多因素logistic回归分析确定独立关联。
共研究了553例患者，其中90例（16.2%）在股骨颈或腰椎存在骨质疏松。糖尿病、肥胖、代谢综合征、超重以及股四头肌力量>30kg、代谢综合征、腹型肥胖和教育水平与较高的骨密度及较低的骨质疏松患病率相关，而年龄、贫血、吸入性糖皮质激素和骨折史与较低的骨密度及较高的骨质疏松患病率相关（P=0.001）。在对所有协变量进行调整后，骨质疏松仅与糖尿病、肥胖、超重和股四头肌力量>30kg呈负相关，与贫血和骨折史呈正相关。骨质疏松与其他参数的关联未达到统计学意义。
该研究结果表明，在老年男性中，糖尿病、肥胖和较高的肌肉力量与较低的骨质疏松患病率相关，贫血和既往骨折则与较高的骨质疏松风险相关。这一问题需要进一步的纵向研究。
