Plasma Kallikrein Inhibitors for the Treatment of Retinal Vascular Permeability Associated with Diabetic Retinopathy and Diabetic Macular Edema.
作者信息
Abdel-Magid Ahmed F
机构信息
Therachem Research Medilab (India) Pvt. Ltd., Jaipur, India.
出版信息
ACS Med Chem Lett. 2017 Jul 11;8(8):776-777. doi: 10.1021/acsmedchemlett.7b00253. eCollection 2017 Aug 10.
Abstract
摘要
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Plasma Kallikrein Inhibitors for the Treatment of Retinal Vascular Permeability Associated with Diabetic Retinopathy and Diabetic Macular Edema.用于治疗与糖尿病视网膜病变和糖尿病性黄斑水肿相关的视网膜血管通透性的血浆激肽释放酶抑制剂
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Targeting the kallikrein-kinin system as a new therapeutic approach to diabetic retinopathy.靶向激肽释放酶-激肽系统作为糖尿病视网膜病变的一种新治疗方法。
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Plasma Kallikrein Mediates Vascular Endothelial Growth Factor-Induced Retinal Dysfunction and Thickening.血浆激肽释放酶介导血管内皮生长因子诱导的视网膜功能障碍和增厚。
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Peripheral vessel leakage (PVL): a new angiographic finding in diabetic retinopathy identified with ultra wide-field fluorescein angiography.外周血管渗漏（PVL）：糖尿病视网膜病变中通过超广角荧光素血管造影术发现的一种新的血管造影表现。
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[Kallikrein-kinin system as a target for diabetic retinopathy treatment].[激肽释放酶-激肽系统作为糖尿病视网膜病变治疗的靶点]
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Kallikrein-kinin activation by altered vitreous pH: New perspectives for treatment and pathogenesis of diabetic macular edema? : Comment on: Gao BB et al. Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. Nat Med. 2007 Feb;13(2):181-8.玻璃体pH值改变激活激肽释放酶-激肽系统：糖尿病性黄斑水肿治疗与发病机制的新视角？：对以下文献的评论：高BB等人。细胞外碳酸酐酶通过激活前激肽释放酶介导视网膜和脑血管出血性通透性增加。《自然医学》。2007年2月；13(2):181 - 8。
Graefes Arch Clin Exp Ophthalmol. 2007 Dec;245(12):1745-7. doi: 10.1007/s00417-007-0673-7. Epub 2007 Sep 6.
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Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation.细胞外碳酸酐酶通过激肽释放酶原激活介导视网膜出血和脑血管通透性。
Nat Med. 2007 Feb;13(2):181-8. doi: 10.1038/nm1534. Epub 2007 Jan 28.
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本文引用的文献
1
Kallikrein-Kinin System: An Emerging Competitor or Collaborator for VEGF in Diabetic Macular Edema?激肽释放酶-激肽系统：糖尿病性黄斑水肿中血管内皮生长因子的新对手还是合作伙伴？
Diabetes. 2015 Oct;64(10):3350-2. doi: 10.2337/db15-0746.
2
Plasma Kallikrein Inhibitors in Cardiovascular Disease: An Innovative Therapeutic Approach.心血管疾病中的血浆激肽释放酶抑制剂：一种创新的治疗方法。
Cardiol Rev. 2016 May-Jun;24(3):99-109. doi: 10.1097/CRD.0000000000000069.
3
The kallikrein system in retinal damage/protection.视网膜损伤/保护中的激肽释放酶系统。
Eur J Pharmacol. 2015 Feb 15;749:161-3. doi: 10.1016/j.ejphar.2014.10.007. Epub 2014 Oct 18.
4
Role of plasma kallikrein in diabetes and metabolism.血浆激肽释放酶在糖尿病和代谢中的作用。
Thromb Haemost. 2013 Sep;110(3):434-41. doi: 10.1160/TH13-02-0179. Epub 2013 May 16.
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