Iarovaia G A, Neshkova E A, Blokhina T B, Kochergin S A, Vorob'eva I V, Gigineishvili D N
Vestn Oftalmol. 2012 Jul-Aug;128(4):78-81.
Multifactor etiology of diabetic retinopathy (DR) determines difficulty of understanding of pathogenesis and need of search of effective approaches to study key mechanisms of development of this microvascular complication of diabetes mellitus (DM). Significant achievements of the last years show the contribution of two proteolytic systems into pathogenesis of DR, that control vascular tone and permeability - kallikrein-kinin (KKS) and renin-angiotensin systems (RAS). Among new approaches to DR treatment one of the most appropriate is an influence on KKS by means of inhibiting kallikrein, that leads to reduction of retinal vascular permeability and allows to prevent the development of macula oedema and other consequences of vascular wall damage in DR.
糖尿病视网膜病变（DR）的多因素病因决定了理解其发病机制的难度，以及寻找有效方法来研究糖尿病（DM）这种微血管并发症发展关键机制的必要性。过去几年的重大进展表明，两种蛋白水解系统在DR发病机制中发挥了作用，它们控制血管张力和通透性——激肽释放酶-激肽系统（KKS）和肾素-血管紧张素系统（RAS）。在DR治疗的新方法中，最合适的方法之一是通过抑制激肽释放酶来影响KKS，这会降低视网膜血管通透性，并有助于预防黄斑水肿的发展以及DR中血管壁损伤的其他后果。
