Department of Experimental Medicine, Section of Medical Pathophysiology, Food Science and Endocrinology, Sapienza University of Rome, Viale del Policlinico 155, 00161, Rome, Italy.
Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Acta Diabetol. 2017 Oct;54(10):961-967. doi: 10.1007/s00592-017-1039-1. Epub 2017 Aug 23.
Interleukin-8 (IL-8) is a chemokine involved in systemic immunity, macrophages infiltration and activation in adipose tissue and may play a significant role in the pathogenesis of type 2 diabetes (T2D) and atherosclerosis. Aims of this study were to evaluate circulating IL-8 levels in adult patients with T2D in comparison with non-diabetic subjects and to describe clinical and biochemical correlates of IL-8 concentration.
For this cross-sectional study, we enrolled 79 consecutive T2D individuals referring to our diabetes outpatient clinics at Sapienza University of Rome, and 37 sex, age and BMI comparable non-diabetic subjects as a control group. Clinical parameters and medical history were recorded; fasting blood sampling was performed for biochemistry and for measuring serum IL-8, IL-6, TNF-α, CRP, adiponectin and 25(OH)vitamin D [25(OH)D] levels.
Patients with T2D exhibited significantly higher serum IL-8 levels than non-diabetic subjects (69.27 ± 112.83 vs. 16.03 ± 24.27 pg/mL, p < 0.001). In diabetic patients, increased IL-8 concentration correlated with higher IL-6 (p < 0.001), TNF-α (p = 0.02), FBG (p = 0.035), HbA1c (p = 0.04) and LDL-C (p = 0.04) and with lower adiponectin (p = 0.02) and 25(OH)D (p = 0.003) concentrations.
Patients with T2D display a marked elevation of circulating IL-8 levels which identify subjects with worse inflammatory, glycometabolic and lipid profile and lower vitamin D levels. Further studies are warranted for evaluating a possible role of IL-8 as a novel marker for risk stratification in T2D patients.
白细胞介素-8（IL-8）是一种参与全身免疫、巨噬细胞浸润和脂肪组织激活的趋化因子，可能在 2 型糖尿病（T2D）和动脉粥样硬化的发病机制中发挥重要作用。本研究旨在评估成年 T2D 患者与非糖尿病患者相比循环 IL-8 水平，并描述 IL-8 浓度的临床和生化相关性。
本横断面研究纳入了 79 例连续就诊于罗马萨皮恩扎大学糖尿病门诊的 T2D 患者，并纳入了 37 名性别、年龄和 BMI 相匹配的非糖尿病患者作为对照组。记录临床参数和病史；空腹采血进行生化检查，并检测血清 IL-8、IL-6、TNF-α、CRP、脂联素和 25（OH）维生素 D [25（OH）D]水平。
T2D 患者的血清 IL-8 水平明显高于非糖尿病患者（69.27±112.83 与 16.03±24.27 pg/mL，p<0.001）。在糖尿病患者中，IL-8 浓度的增加与更高的 IL-6（p<0.001）、TNF-α（p=0.02）、FBG（p=0.035）、HbA1c（p=0.04）和 LDL-C（p=0.04）以及更低的脂联素（p=0.02）和 25（OH）D（p=0.003）浓度相关。
T2D 患者表现出循环 IL-8 水平的明显升高，这些患者具有更严重的炎症、糖代谢和血脂谱以及更低的维生素 D 水平。需要进一步研究评估 IL-8 是否可作为 T2D 患者风险分层的新型标志物。
